依达拉奉注射液联合瓜蒌皮注射液治疗急性缺血性脑卒中的临床研究

发布时间：2018-08-11 14:46

【摘要】：目的观察依达拉奉注射液联合瓜蒌皮注射液治疗急性缺血性脑卒中的临床疗效及安全性。方法将134例急性缺血性脑卒中患者随机分为对照组67例和试验组67例。对照组予以依达拉奉注射液30 mg,qd,静脉滴注;试验组在对照组治疗的基础上,予以瓜蒌皮注射液20 m L,qd,静脉滴注。2组患者均治疗12 d。比较2组患者的临床疗效、神经功能缺损(NIHSS)评分和生活自理能力(BI)评分、C反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的水平,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为92.54%(62/67例)和76.12%(51/67例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的NIHSS评分分别为(11.91±2.33)和(13.21±3.35)分,BI评估量表评分分别为(62.32±12.83)和(52.72±16.53)分,CRP分别为(3.92±1.15)和(7.12±1.96)mg·d L-1,IL-6分别为(15.54±4.93)和(19.23±3.84)ng·L-1,TNF-α分别为(26.85±8.75)和(43.73±12.52)ng·m L-1,差异均有统计学意义(均P0.05)。试验期间,2组患者均未发生药物不良反应。结论依达拉奉注射液联合瓜蒌皮注射液治疗急性缺血性脑卒中的临床疗效确切,其能明显降低患者的神经功能缺损程度,改善血清炎症因子水平,且安全性较高。
[Abstract]:Objective to observe the clinical efficacy and safety of Edaravone injection combined with Gualoupi injection in the treatment of acute ischemic stroke. Methods 134 patients with acute ischemic stroke were randomly divided into control group (67 cases) and experimental group (67 cases). The control group was treated with Edaravone injection 30 mg / g QD, and the experimental group was treated with Gualoupi injection 20 m / L QD on the basis of the control group, and all the patients in the control group were treated for 12 days by intravenous drip of Edaravone injection. The clinical efficacy, (NIHSS) score of neurological impairment and (BI) score of self-care ability were compared between the two groups. The levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor- 伪 (TNF- 伪), and the occurrence of adverse drug reactions were compared. Results after treatment, the total effective rates of the experimental group and the control group were 92.54% (62 / 67 cases) and 76.12% (51 / 67 cases), respectively. The difference was statistically significant (P0.05). After treatment, the NIHSS scores of the test group and the control group were (11.91 卤2.33) and (13.21 卤3.35) respectively (62.32 卤12.83) and (52.72 卤16.53), respectively. The scores of NIHSS were (3.92 卤1.15) and (7.12 卤1.96) mg d L ~ (-1) and (15.54 卤4.93) and (19.23 卤3.84) ng / L ~ (-1) ng m L ~ (-1), respectively (26.85 卤8.75) and (43.73 卤12.52) ng m L ~ (-1), respectively (P 0.05). There were no adverse drug reactions in both groups during the trial. Conclusion Edaravone injection combined with trichosanthes peel injection is effective in the treatment of acute ischemic stroke. Edaravone injection can obviously reduce the degree of neurological deficit and improve the level of serum inflammatory factors.
【作者单位】：海口市人民医院神经内科;海南省农垦总局医院神经外科;
【基金】：海南省自然科学基金资助项目(814375)
【分类号】：R743.3

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