幽门螺杆菌感染与急性心肌梗死患者血清炎症反应的关系研究

发布时间：2018-09-03 16:16

【摘要】：目的探讨幽门螺杆菌(Hp)感染与急性心肌梗死(AMI)患者血清炎症反应的关系,为临床防治AMI提供参考。方法选取2013年4月-2014年11月医院收治的74例AMI患者,设为研究组;另选取同期在医院进行体检的74名健康人设为对照组;采用酶联免疫法(ELISA)对两组Hp免疫球蛋白G(IgG)浓度进行测定,并检测两组患者血清白细胞介素6(IL-6)、IL-8、IL-18、肿瘤坏死因子-α(TNF-α)和高敏C-反应蛋白(hs-CRP)水平,分析Hp IgG阳性与血清炎症因子的相关性;采用SPSS15.0软件进行统计分析。结果研究组患者的Hp阳性率为72.97%,明显高于对照组的51.35%,差异有统计学意义(χ2=8.933,P0.01);Hp阳性患者IL-6、IL-8、IL-18、TNF-α、hs-CRP明显高于Hp阴性患者,差异均有统计学意义(P0.05);相关性分析显示,Hp IgG阳性与血清IL-6、IL-8、IL-18、TNF-α、hs-CRP呈显著的正相关(P0.05),相关系数分别为0.735、0.644、0.798、0.674、0.616。结论 Hp感染与AMI患者血清炎症反应间存在密切关系,两者相互影响,进而促进AMI的病情进展。
[Abstract]:Objective To explore the relationship between Helicobacter pylori (Hp) infection and serum inflammatory reaction in patients with acute myocardial infarction (AMI) and to provide reference for clinical prevention and treatment of AMI. Methods Serum levels of interleukin-6 (IL-6), interleukin-8, interleukin-18, tumor necrosis factor-alpha (TNF-alpha) and high-sensitivity C-reactive protein (hs-CRP) in the two groups were measured by ELISA, and the correlation between Hp-IgG positive and serum inflammatory factors was analyzed by SPSS15.0 software. Hp positive rate was 72.97%, significantly higher than 51.35% of the control group, the difference was statistically significant (2 = 8.933, P 0.01); Hp positive patients with IL-6, IL-8, IL-18, TNF-a, hs-CRP were significantly higher than those with negative Hp, the difference was statistically significant (P 0.05); Correlation analysis showed that Hp IgG positive and serum IL-6, IL-8, IL-18, TNF-a, hs-CRP were significantly positively correlated (P 0.05). The correlation coefficients were 0.735, 0.644, 0.798, 0.674 and 0.616, respectively. Conclusion There is a close relationship between Hp infection and serum inflammation in patients with AMI, and the interaction between them can promote the progression of AMI.
【作者单位】：河南大学淮河医院干部病房;
【基金】：国家自然科学基金青年基金资助项目(81001645)
【分类号】：R542.22

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