血清25-羟维生素D3水平预测老年急性ST段抬高性心肌梗死患者发生恶性室性心律失常的价值
发布时间:2018-09-12 07:01
【摘要】:目的探讨血清25羟维生素D3〔25-(OH)D3〕水平预测老年急性ST段抬高性心肌梗死(ASTEMI)患者发生恶性室性心律失常(MVA)的价值。方法 132例ASTEMI患者按照血清25-(OH)D3水平分为25-(OH)D3缺乏组(B组,50 nmol/L,n=54)及25-(OH)D3正常组(A组,≥50 nmol/L,n=78),记录两组患者一般临床资料、实验室检查指标及MVA的发生率。利用Logistic回归方程分析血清25-(OH)D3水平与MVA发生的关系,并利用ROC曲线分析血清25-(OH)D3水平预测MVA发生的临床价值。结果与A组比较,B组患者糖尿病、多支血管病变比例较高,Killip心功能分级较差(P0.05);B组入院时血糖、血清肌酸激酶同工酶(CK-MB)、肌钙蛋白(c Tn)I、B型脑钠肽(BNP)、高敏C反应蛋白(hsCRP)高于A组(P0.05),左室射血分数(LVEF)低于A组(P0.05);MVA的发生率高于A组(P0.05);Pearson相关分析及多元线性回归方程显示,25-(OH)D3水平与入院时血糖、血清BNP、c Tn I、CK-MB、hs-CRP呈正相关(P0.05),而与LVEF呈正负关(P0.05);多因素Logistic回归分析显示:血清25-(OH)D3缺乏(50 nmol/L)是ASTEMI患者发生MVA的独立危险因素(OR=1.137,95%CI:1.033~1.309,P0.05);ROC曲线分析显示:血清25-(OH)D3水平预测MVA的曲线下面积(AUC)为0.859,灵敏度和特异度分别为83.6%,77.9%,最佳诊断截点为42.30 nmol/L。结论血清25-(OH)D3缺乏可能是ASTEMI患者发生MVA的独立预测因素,应当重视血清25-(OH)D3水平的检测,及时补充Vit D以降低患者MVA的发生风险,以改善患者预后。
[Abstract]:Objective to evaluate the value of serum 25-hydroxyvitamin D _ 3 (25-hydroxyvitamin D _ 3) level in predicting malignant ventricular arrhythmia (MVA) in elderly patients with acute ST segment elevation myocardial infarction (ASTEMI). Methods 132 patients with ASTEMI were divided into 25- (OH) D3 deficient group (group B) and 25 (OH) D3 normal group (group A, 鈮,
本文编号:2238260
[Abstract]:Objective to evaluate the value of serum 25-hydroxyvitamin D _ 3 (25-hydroxyvitamin D _ 3) level in predicting malignant ventricular arrhythmia (MVA) in elderly patients with acute ST segment elevation myocardial infarction (ASTEMI). Methods 132 patients with ASTEMI were divided into 25- (OH) D3 deficient group (group B) and 25 (OH) D3 normal group (group A, 鈮,
本文编号:2238260
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