微小RNA对中国急性心肌梗死患者早期诊断价值的Meta分析
发布时间：2018-09-12 10:16
【摘要】：目的:评价微小RNA(miRNAs)对中国急性心肌梗死(AMI)患者的早期诊断价值。方法:采用Cochrane系统评价的基本方法,全面检索Pubmed、Medline、Web of science、中国期刊全网全文数据库(CNKI)、万方数据库、中国生物医学文献数据库,无语言限制,搜集评价miRNAs对中国AMI患者诊断价值的文献,以灵敏度(Sen)、特异度(Spe)、诊断优势比(DOR)及受试者工作特征曲线下面积(SROC)作为诊断效能的评价指标,采用MetaDisc1.4软件进行系统评价和Meta分析。结果:共纳入24篇文献,其中英文15篇,中文9篇。Meta分析结果显示:总miRNAs的合并Sen、Spe和SROC面积分别为0.73(95%CI:0.72~0.75)、0.82(95%CI:0.81~0.84)和0.8783;miRNA-499的合并Sen、Spe和SROC面积为0.78(95%CI:0.75~0.81)、0.76(95%CI:0.72~0.79)和0.8781;miRNA-1的合并Sen、Spe和SROC面积为0.73(95%CI:0.69~0.78)、0.84(95%CI:0.80~0.87)和0.8374;miRNA-208的合并Sen、Spe和SROC面积为0.73(95%CI:0.68~0.77)、0.85(95%CI:0.80~0.88)和0.8658;miRNA-133的合并Sen、Spe和SROC面积为0.75(95%CI:0.70~0.80)、0.88(95%CI:0.84~0.92)和0.9391。结论:miRNA是一种新型的心脏损伤标志物,尤其miRNA-133对早期AMI具有较强的诊断价值,但仍需要更大样本高质量的临床试验加以验证。
[Abstract]:Objective: to evaluate the value of small RNA (miRNAs) in early diagnosis of (AMI) patients with acute myocardial infarction in China. Methods: the basic method of Cochrane system evaluation was used to search the Pubmed,Medline,Web of science, full text database of Chinese periodicals, (CNKI), Wanfang database and Chinese biomedical literature database without language restriction. Literature on the diagnostic value of miRNAs in Chinese AMI patients was collected. The diagnostic advantage ratio of sensitivity (Sen), specificity to (Spe), and the area (SROC) under the operating characteristic curve of the subjects were used as the evaluation index of diagnostic efficacy. MetaDisc1.4 software was used for systematic evaluation and Meta analysis. Results: a total of 24 articles were included, 15 of which were in English and Chinese. 涓枃9绡，
本文编号：2238697
[Abstract]:Objective: to evaluate the value of small RNA (miRNAs) in early diagnosis of (AMI) patients with acute myocardial infarction in China. Methods: the basic method of Cochrane system evaluation was used to search the Pubmed,Medline,Web of science, full text database of Chinese periodicals, (CNKI), Wanfang database and Chinese biomedical literature database without language restriction. Literature on the diagnostic value of miRNAs in Chinese AMI patients was collected. The diagnostic advantage ratio of sensitivity (Sen), specificity to (Spe), and the area (SROC) under the operating characteristic curve of the subjects were used as the evaluation index of diagnostic efficacy. MetaDisc1.4 software was used for systematic evaluation and Meta analysis. Results: a total of 24 articles were included, 15 of which were in English and Chinese. 涓枃9绡，
本文编号：2238697
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