降钙素原对急性严重心力衰竭预后价值的分析

发布时间：2018-10-05 18:07

【摘要】：目的:探讨降钙素原(PCT)与急性严重心力衰竭临床预后的相关性。方法:收集诊断为急性严重心力衰竭而无活动性感染的患者共88例。根据PCT升高与否将88例分为PCT升高组、PCT不升高组,记录其临床特点、相关检查结果、住院期间死亡事件,随访患者出院1年内再住院事件及心源性死亡事件。结果:PCT升高组较PCT不升高组有更严重的多脏器灌注受损指标和更高的住院期间死亡事件、出院后1年内再住院事件及心源性死亡事件发生率(P0.05)。PCT对急性严重心力衰竭而无活动性感染患者住院期间死亡事件、1年内再住院事件及心源性死亡事件的ROC曲线下面积分别为:0.72、0.65、0.73,灵敏度:0.82、0.51、0.48,特异度:0.56、0.80、0.89。结论:血清PCT值与急性严重心力衰竭而无活动性感染患者的临床预后显著相关,可作为临床预后评估的一项新的独立的重要化验指标。
[Abstract]:Objective: to investigate the relationship between procalcitonin (PCT) and clinical prognosis of acute severe heart failure. Methods: 88 patients with acute and severe heart failure without active infection were collected. According to the elevation of PCT, 88 cases were divided into two groups. The clinical features, related examination results, death events during hospitalization, rehospitalization events and cardiac death events were recorded. Results there were more severe multiple organ perfusion impairment and higher death events during hospitalization in the group with elevated PCT than those with no increase in PCT. Incidence of readmission events and cardiogenic death events within one year after discharge (P0.05). Under the ROC curve for patients with acute and severe heart failure without active infection, the incidence of in-hospital events, rehospitalization events and cardiac death events within one year The area was 0.72 / 0.65 / 0.73, the sensitivity was 0.82 / 0.51 / 0.48, and the specificity was 0.86 / 0.80 / 0.89. Conclusion: the serum PCT level is significantly correlated with the clinical prognosis of patients with acute severe heart failure and inactive infection. It can be used as a new independent laboratory index to evaluate the prognosis of patients with acute heart failure.
【作者单位】：华中科技大学协和医院心内科;华中科技大学附属梨园医院心内科;
【基金】：国家自然科学基金资助(No:81470483)
【分类号】：R541.6

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