左西孟旦改善急性有机磷农药中毒患者心功能效果观察
发布时间：2018-10-19 07:19
【摘要】：目的探讨左西孟旦对急性有机磷农药中毒(AOPP)所致心功能不全患者心功能的影响。方法选取AOPP所致心功能不全的患者51例,随机分为对照组26例、治疗组25例。两组均给予内科常规联合血液灌流(HP)及连续性静脉-静脉血液滤过(CVVH)的基础治疗,对照组采用微量泵持续泵入多巴酚丁胺,治疗组采用微量泵持续泵入左西孟旦注射液。治疗前及治疗后12、24、48 h行超声心动图检查,测算左心室射血分数(LVEF)、左心室舒张末期内径(LVIDd),抽取外周静脉血检测血浆B型脑钠肽(BNP)水平。记录两组28 d死亡例数、机械通气应用时间,计算病死率。结果与治疗前比较,两组治疗后各时间点LVEF均增大,LVIDd及BNP均降低(P均0.05)。与对照组比较,治疗组治疗后各时间点LVEF均增大,LVIDd及BNP均降低(P均0.05)。两组治疗后各时点血浆BNP水平均低于治疗前,治疗组治疗12、24、48 h时血浆BNP水平均低于对照组(P均0.05)。治疗组治疗28 d时病死率低于对照组(P0.05),应用机械通气时间少于对照组(P0.05)。结论左西孟旦能够明显改善AOPP所致心功能不全患者的心功能,并可降低病死率、缩短机械通气治疗时间。
[Abstract]:Objective to investigate the effect of levosimendan on cardiac function in patients with cardiac insufficiency caused by acute organophosphorus pesticide poisoning (AOPP). Methods 51 patients with cardiac dysfunction caused by AOPP were randomly divided into control group (n = 26) and treatment group (n = 25). Both groups were treated with routine internal medicine combined with hemoperfusion of (HP) and continuous veno-venous hemofiltration (CVVH). The control group was continuously pumped into dobutamine by micropump, while the treatment group was treated with micropump continuous pump into levosimendan injection. The left ventricular ejection fraction (LVEF),) and left ventricular end-diastolic diameter (LVIDd),) were measured by echocardiography before treatment and 48 hours after treatment. Peripheral venous blood was extracted to detect the level of B-type brain natriuretic peptide (BNP) (BNP) in plasma. The death cases of 28 days, the duration of mechanical ventilation and the mortality of the two groups were recorded. Results compared with before treatment, LVEF increased, LVIDd and BNP decreased at each time point after treatment in both groups (P0. 05). Compared with the control group, the LVEF increased and the LVIDd and BNP decreased at each time point after treatment in the treatment group. Plasma BNP levels in both groups were lower than those before treatment at all time points after treatment. Plasma BNP levels in the treatment group were lower than those in the control group at 48 h after treatment (P < 0. 05). The fatality rate of the treatment group was lower than that of the control group at 28 days (P0.05), and the time of mechanical ventilation was less than that of the control group (P0.05). Conclusion Levomycin can significantly improve the cardiac function of patients with cardiac insufficiency caused by AOPP, reduce the mortality and shorten the time of mechanical ventilation.
【作者单位】： 单县中心医院;
【分类号】：R595.4
[Abstract]:Objective to investigate the effect of levosimendan on cardiac function in patients with cardiac insufficiency caused by acute organophosphorus pesticide poisoning (AOPP). Methods 51 patients with cardiac dysfunction caused by AOPP were randomly divided into control group (n = 26) and treatment group (n = 25). Both groups were treated with routine internal medicine combined with hemoperfusion of (HP) and continuous veno-venous hemofiltration (CVVH). The control group was continuously pumped into dobutamine by micropump, while the treatment group was treated with micropump continuous pump into levosimendan injection. The left ventricular ejection fraction (LVEF),) and left ventricular end-diastolic diameter (LVIDd),) were measured by echocardiography before treatment and 48 hours after treatment. Peripheral venous blood was extracted to detect the level of B-type brain natriuretic peptide (BNP) (BNP) in plasma. The death cases of 28 days, the duration of mechanical ventilation and the mortality of the two groups were recorded. Results compared with before treatment, LVEF increased, LVIDd and BNP decreased at each time point after treatment in both groups (P0. 05). Compared with the control group, the LVEF increased and the LVIDd and BNP decreased at each time point after treatment in the treatment group. Plasma BNP levels in both groups were lower than those before treatment at all time points after treatment. Plasma BNP levels in the treatment group were lower than those in the control group at 48 h after treatment (P < 0. 05). The fatality rate of the treatment group was lower than that of the control group at 28 days (P0.05), and the time of mechanical ventilation was less than that of the control group (P0.05). Conclusion Levomycin can significantly improve the cardiac function of patients with cardiac insufficiency caused by AOPP, reduce the mortality and shorten the time of mechanical ventilation.
【作者单位】： 单县中心医院;
【分类号】：R595.4
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