连续性血液净化治疗严重脓毒症患者的疗效及对细胞因子的影响

发布时间：2018-11-04 08:59

【摘要】：目的观察连续性血液净化(CBP)治疗严重脓毒症患者的疗效及对细胞因子的影响。方法回顾性分析60例严重脓毒症并接受CBP患者的临床资料,将其分为常规治疗组与CBP治疗组各30例。观察并记录两组0、24、72 h血清中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β、IL-6水平;此外比较两组治疗24 h的急性生理和慢性健康状态评分(APACHE)Ⅱ评分、两组需行机械通气时间。结果 1在入院后经CBP治疗24、72 h患者血清中的TNF-α、IL-1β、IL-6浓度明显下降(P0.05)。CBP治疗组24、72 h患者血液中的TNF-α、IL-1β、IL-6浓度明显低于常规治疗组(P0.05)。2治疗24 h两组APACHEⅡ评分明显降低,CBP治疗组明显低于常规治疗组(P0.05)。3两组需行机械通气时间差异显著(P0.01)。结论及早行CBP治疗可以有效清除血液中的细胞因子,缩短机械通气时间,改善疾病,提高患者预后。
[Abstract]:Objective to observe the effect of continuous blood purification (CBP) in the treatment of severe sepsis. Methods the clinical data of 60 patients with severe sepsis and CBP were analyzed retrospectively and divided into routine treatment group and CBP treatment group. The levels of tumor necrosis factor (TNF)-伪, interleukin (IL)-1 尾 and IL-6 were observed and recorded in the serum of the two groups for 72 h. In addition, the (APACHE) 鈪，

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