单唾液酸四己糖神经节苷脂联合高压氧治疗急性脑梗死的临床疗效

发布时间：2018-11-09 20:42

【摘要】：目的观察单唾液酸四己糖神经节苷脂(GM1)联合高压氧治疗急性脑梗死的临床疗效。方法将80例急性脑梗死患者随机分为常规治疗组(40例)和联合治疗组(40例)。两组均常规予以阿托伐他汀分散片、拜阿司匹林肠溶片、血栓通、巴曲酶治疗,并辅以控制血压、血糖等治疗。联合治疗组在常规治疗基础上予以GM1(生理盐水+GM1 40 mg/d)联合高压氧治疗,疗程10 d。治疗前后分别采用NIHSS、日常生活活动量表(ADL)的Barthel指数评价患者的神经功能;治疗3个月后对患者进行mRS评分。结果治疗前常规治疗组及联合治疗组患者NIHSS评分及Barthel指数差异无统计学意义(均P0.05)。与治疗前比较,常规治疗组及联合治疗组治疗后Barthel指数显著升高,NIHSS评分显著降低(均P0.01)。与常规治疗组比较,联合治疗组治疗后NIHSS评分及mRS评分显著降低,Barthel指数评分显著升高(均P0.05)。联合治疗组总有效率显著高于常规治疗组(χ~2=5.00,P=0.025)。两组患者均未发生明显的不良反应。结论对于未能进行溶栓治疗的急性脑梗死患者,积极予以常规治疗可改善患者预后;在此基础上的进行GM1联合高压氧治疗更能有效促进急性脑梗死患者神经功能状态的康复和远期疗效,且安全有效,值得临床推广。
[Abstract]:Objective to observe the clinical effect of monosialic tetrahexose ganglioside (GM1) combined with hyperbaric oxygen in the treatment of acute cerebral infarction. Methods 80 patients with acute cerebral infarction were randomly divided into routine treatment group (40 cases) and combined treatment group (40 cases). Both groups were treated with Atto vastatin dispersible tablets, aspirin enteric-coated tablets, Xueshuantong, batroxobin, and blood pressure control, blood sugar treatment. The combined treatment group was treated with GM1 (normal saline GM1 40 mg/d) and hyperbaric oxygen on the basis of routine treatment for 10 days. Before and after treatment, the Barthel index of NIHSS, ADL scale (ADL) was used to evaluate the neurological function of the patients, and the mRS score was evaluated after 3 months of treatment. Results there was no significant difference in NIHSS score and Barthel index between routine treatment group and combined treatment group before treatment (P0.05). Compared with before treatment, Barthel index and NIHSS score in routine treatment group and combined treatment group were significantly increased (P0.01). Compared with the conventional treatment group, the combined treatment group after treatment significantly decreased the NIHSS score and mRS score, Barthel index score significantly increased (P0.05). The total effective rate of the combined treatment group was significantly higher than that of the routine treatment group (蠂 ~ 2 ~ 2 ~ 5.00 P0. 025). There were no significant adverse reactions in both groups. Conclusion for patients with acute cerebral infarction who can not be treated with thrombolytic therapy, routine therapy can improve the prognosis of the patients. On this basis, GM1 combined with hyperbaric oxygen therapy can effectively promote the rehabilitation and long-term effect of neurological function in patients with acute cerebral infarction, and it is safe and effective, and worthy of clinical promotion.
【作者单位】：苏州市第七人民医院神经内科;苏州大学附属第二医院神经内科;
【分类号】：R743.3

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