心脏手术后无菌性SIRS继发MODS患者血清CRP、NT-proBNP水平变化及意义

发布时间：2018-11-17 17:17

【摘要】：目的观察心脏手术后无菌性全身炎症反应综合征(SIRS)继发多器官功能障碍综合征(MODS)患者血清CRP、N端脑钠肽(NT-pro BNP)水平变化,探讨其与患者病情及预后的关系。方法选择行心脏手术后发生无菌性SIRS继发MODS患者35例(观察组),同期行心脏手术后未发生MODS患者35例(对照组)。采用AU5400全自动生化分析仪检测两组血清CRP、NT-pro BNP,分析观察组MODS评分、住院期间生存情况与血清CRP、NT-pro BNP的关系。结果观察组血清CRP水平明显高于对照组(P0.05),两组血清NT-pro BNP水平比较差异无统计学意义(P0.05)。观察组血清CRP与MODS评分呈正相关(r=0.918,P0.05),血清NT-pro BNP与MODS评分无明显相关性(r=0.297,P0.05)。观察组术后住院时间(21±5)d,对照组为(8±2)d,两组比较P0.05。观察组住院期间存活29例、死亡6例,存活者血清CRP水平明显低于死亡者(P0.05),不同预后者血清NT-pro BNP水平比较差异无统计学意义(P0.05)。结论心脏手术后无菌性SIRS继发MODS患者血清CRP水平升高,血清NT-pro BNP水平无明显变化;血清CRP水平有助于评估患者病情及判断预后。
[Abstract]:Objective to observe the changes of serum CRP,N terminal brain natriuretic peptide (NT-pro BNP) levels in patients with aseptic systemic inflammatory response syndrome (SIRS) secondary to multiple organ dysfunction syndrome (MODS) after cardiac surgery. Methods 35 cases of MODS secondary to aseptic SIRS were selected after cardiac surgery (observation group) and 35 cases of patients without MODS after cardiac surgery (control group). AU5400 automatic biochemistry analyzer was used to detect the MODS score of the two groups of serum CRP,NT-pro BNP, analysis observation group, and the relationship between the survival condition and serum CRP,NT-pro BNP during hospitalization. Results the serum CRP level in the observation group was significantly higher than that in the control group (P0.05). There was no significant difference in the serum NT-pro BNP level between the two groups (P0.05). There was a positive correlation between serum CRP and MODS score in the observation group (r = 0.918 P 0.05), but no significant correlation between the serum NT-pro BNP score and the MODS score (r = 0.297 P 0.05). The hospital stay was (21 卤5) d in the observation group and (8 卤2) d in the control group (P < 0.05). In the observation group, 29 cases survived and 6 cases died. The serum CRP level of the survivors was significantly lower than that of the dead (P0.05). There was no significant difference in the serum NT-pro BNP levels between the patients with different prognosis (P0.05). Conclusion after cardiac surgery, the level of serum CRP in patients with MODS secondary to aseptic SIRS is increased, but the level of serum NT-pro BNP does not change significantly, and the level of serum CRP is helpful to evaluate the condition of the patients and to judge the prognosis.
【作者单位】：海南省人民医院;
【基金】：海南省自然科学基金项目(814306) 海南省医学普通科研课题(琼卫2012PT-07)
【分类号】：R654.2

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