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跑台运动促进幼龄大鼠学习能力

发布时间：2017-01-05 12:31

本文关键词：跑台运动对轻度脑外伤大鼠空间学习记忆能力及海马BDNF表达的影响，由笔耕文化传播整理发布。

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跑台运动促进幼龄大鼠学习能力

生理学报 Acta Physiologica Sinica, August 25, 2006, 58 (4): 365-369

365

研究论文

跑台运动促进幼龄大鼠学习能力

娄淑杰**,*，刘瑾彦**，杨若愚，陈佩杰

上海体育学院运动人体科学系，运动分子生物学研究中心，上海 200438

摘要：为了探讨跑台运动对幼龄大鼠学习能力的影响，实验采用5周龄Sprague-Dawley大鼠，随机分为安静对照组和跑台运动组，其中跑台运动组大鼠以低强度进行为期一周的跑台运动；然后使用Morris水迷宫，对两组大鼠的定位航行和空间探索能力进行分析。在定位航行实验中，运动组大鼠寻找到平台的潜伏期明显短于对照组(P<0.05); 并且随着训练次数的增加，运动组大鼠的游泳速度明显高于对照组(P<0.01); 另外，运动轨迹的弯曲度表明运动组大鼠还表现出了较强的寻找平台的动机以及对平台位置较为准确的空间定位能力。在空间探索实验中，两组大鼠的游泳速度并没有明显差异，从大鼠在各象限内穿越平台相应位置的次数来看，运动组大鼠在D象限穿越的次数高于对照组，但无统计学差异(P>0.05)。上述结果提示，低强度的跑台运动在短时间内便可以明显提高幼龄大鼠的学习能力。

关键词：运动；迷宫学习；幼龄；大鼠

中图分类号：Q42

Treadmill running enhances the ability of learning in young rats

LOU Shu-Jie**,*, LIU Jin-Yan**, YANG Ruo-Yu, CHEN Pei-Jie

Exercise Molecular Biology Research Center, Department of Exercise and Sports Science, Shanghai University of Sport, Shanghai200438, China

Abstract: To investigate the effect of treadmill running on the ability of learning in young rats, male Sprague-Dawley rats (5 weeks ofage) were used for the experiment. Animals were randomly divided into the control and running groups (n=15 in each group). The ratsin running group were made run on a motor-driven treadmill for 1 week at a speed of 2 m/min for the first 5 min, at a speed of 5 m/minfor the next 5 min, then at a speed of 8 m/min for the last 20 min. Then the Morris water maze was used to observe learning and memoryability of rats in both groups. The tests consisted of place navigation and spatial probe test. We found that, in place navigation training,the latency of rats in running group was less than that in control group (P<0.05); and from the third training session on, there was significantdifference between the rats in control and running groups in swimming velocity (P<0.01); furthemore, it was observed that the rats inrunning group had stronger motivation and more exact orientation in searching for platform, which could be indicated by the index ofturn angle and angular velocity. In spatial probe test, there was no significant difference between the two groups in swimming velocity,percentage of swimming distance and frequency of crossing platform in D quadrant, where the platform situated (P>0.05). These findingssuggest that low speed treadmill running can enhance the ability of learning in young rats.

Key words: exercise; maze learning; young age; rats

学习是神经系统接受外界环境信息的刺激而获

得新行为、新习惯的过程，记忆则是指获得的信息或经验在脑内储存、加工和提取的过程。对人而言，学习记忆能力是影响认知水平的重要因素。因

Received 2005-10-08 Accepted 2006-05-03

This work was supported by the National Natural Science Foundation of China (No. 30570899), Natural Science Foundation ofShanghai (No. 04ZR14124) and the Key Department Development Program of Shanghai (No. T0901).

*Contributed equally to this work.Corresponding author. Tel: +86-21-51253249; Fax: +86-21-51253242; E-mail: shujielou319@

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