降钙素原、胆碱酯酶及肌钙蛋白对不同程度脓毒症患者病情分析及预后的影响

发布时间：2018-12-14 02:26

【摘要】：目的探讨降钙素原(PCT)、胆碱酯酶(ChE)以及肌钙蛋白I(cCTnI)对分析脓毒症不同程度病情、评估预后的临床实用性。方法选取2012年3月-2015年3月医院收治107例脓毒症患者作为研究对象,根据病情不同程度将其分为脓毒症组45例、严重脓毒症组38例、脓毒症休克组24例,根据入院28d内是否死亡将其分为死亡组22例和存活组85例,分别于入院24h、第3天、第5天检测患者PCT、ChE以及CTnI,比较各组间的指标水平。结果入院时,脓毒症休克组和严重脓毒症组PCT、CTnI显著高于脓毒症组,且脓毒症休克组PCT、CTnI又显著高于严重脓毒症组,差异均有统计学意义(P0.05);脓毒症休克组和严重脓毒症组ChE显著低于脓毒症组,且脓毒症休克组ChE又显著低于严重脓毒症组,差异均有统计学意义(P0.05);死亡组各时间点PCT和CTnI水平均显著高于存活组,ChE水平均显著低于存活组,差异有统计学意义(P0.05)。结论 PCT、ChE以及CTnI可用于分析脓毒症不同程度病情、评估预后,具有较好的临床实用性。
[Abstract]:Objective to investigate the clinical usefulness of calcitonin proto (PCT), cholinesterase (ChE) and troponin I (cCTnI) in the analysis of different degrees of sepsis and in the evaluation of prognosis. Methods from March 2012 to March 2015, 107 patients with sepsis were divided into sepsis group (n = 45), severe sepsis group (n = 38) and septic shock group (n = 24). The patients were divided into death group (n = 22) and survival group (n = 85) according to whether they died within 28 days after admission. PCT,ChE and CTnI, were measured at 24 hours, 3 days and 5 days respectively. Results on admission, the PCT,CTnI of septic shock group and severe sepsis group was significantly higher than that of septic group, and the PCT,CTnI of septic shock group was significantly higher than that of severe sepsis group (P0.05). The ChE of septic shock group and severe sepsis group was significantly lower than that of septic group, and the ChE of septic shock group was significantly lower than that of severe sepsis group (P0.05). The levels of PCT and CTnI in the death group were significantly higher than those in the survival group at each time point, and the ChE level was significantly lower than that in the survival group (P0.05). Conclusion PCT,ChE and CTnI can be used to analyze different degree of sepsis and evaluate prognosis.
【作者单位】：广州军区总医院ICU科;
【基金】：广东省自然科学基金资助项目(05000139)
【分类号】：R459.7

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