MMP-9与急性STEMI患者介入治疗近期ISR的关联性研究

发布时间：2019-03-31 19:21

【摘要】：目的观察基质金属蛋白酶-9(MMP-9)与急性ST段抬高心肌梗死(STEMI)接受经皮冠状动脉介入(PCI)治疗并置入药物涂层支架的患者近期支架内再狭窄(ISR)的关系。方法选择2010年3月至2013年3月在该院接受介入治疗的STEMI患者210例为观察对象,按照是否发生ISR,分为ISR组33例与无ISR组177例,测量并比较两组外弹力膜横截面面积、斑块面积、最小管腔面积及内膜增生面积;术前及随访时均检测MMP-9水平。结果 ISR组患者MMP-9水平在随访节点明显高于非ISR组,ROC曲线分析发现,以MMP-9≥2.425ng/mL为诊断分界值预测ISR的发生,其曲线下面积(AUC)为0.834(95%CI:0.745~0.923),敏感度0.697,特异性0.915,约登指数0.612,具有较好的诊断价值。MMP-9升高的患者外弹力膜横截面积、内膜增生面积及斑块面积大于不升高患者,而最小管腔面积低于不升高患者,差异有统计学意义(P0.05)。结论 PCI术后ISR患者MMP-9水平较术前升高,监测MMP-9水平对PCI术后ISR有一定的预测作用。
[Abstract]:Objective to investigate the relationship between matrix metalloproteinase-9 (MMP-9) and in-stent restenosis (ISR) in patients with acute ST segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) and implanted with drug-coated stents. Methods from March 2010 to March 2013, 210 patients with STEMI were divided into ISR group (n = 33) and non-ISR group (n = 177). The cross-sectional area of external elastic membrane and plaque area were measured and compared between the two groups. Minimum lumen area and intimal hyperplasia area; The levels of MMP-9 were measured before and after follow-up. Results the level of MMP-9 in ISR group was significantly higher than that in non-ISR group. ROC curve analysis showed that MMP-9 鈮，

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