急性心肌梗死合并心室震颤与基质金属蛋白酶-9、基质金属蛋白酶组织抑制剂-1的相关性

发布时间：2019-04-27 13:15

【摘要】：目的探讨急性心肌梗死合并心室震颤(NF)与急性期基质金属蛋白酶(MMP)-9及基质金属蛋白酶组织抑制剂(TIMP)-1表达水平。方法 10例急性心肌梗死合并VF患者纳入实验组;同期10例急性心肌梗死未合并VF患者作为对照组。比较两组患者MMP-9与TIMP-1及空腹血糖、总胆固醇、甘油三酯、超敏C反应蛋白水平。结果实验组第1天MMP-9基因表达比对照组高1.73倍(1.03~2.96),第3天MMP-9基因表达比对照组高1.54倍(1.09~2.92),第5天MMP-9基因表达比对照组高1.61倍(1.07~3.09)(均P0.05);实验组TIMP-1水平显著高于同时相点对照组TIMP-1水平(P均0.05)。同时相点,实验组血清MMP-9与TIMP-1均呈明显正相关(均P0.05)。急性心肌梗死合并VF与hs-CRP(OR:1.742,95%CI:1.896~3.467)、收缩压(OR:2.835,95%CI:1.896~3.467)、空腹血糖(OR:1.801,95%CI:1.436~2.347)均呈正相关(P均0.05)。结论急性心肌梗死合并VF与血清MMP-9、TIMP-1水平升高存在关联性,即高水平的MMP-9和TIMP-1预示急性心肌梗死患者发生VF的可能性更高。
[Abstract]:Objective to investigate the expression levels of (NF), (MMP)-9 and (TIMP)-1 in acute myocardial infarction (AMI) complicated with ventricular tremor (VTF) and tissue inhibitor of metalloproteinase-1 (MMP-1) in acute myocardial infarction (AMI). Methods Ten patients with acute myocardial infarction complicated with VF were enrolled in the experimental group, and 10 patients with non-acute myocardial infarction complicated with VF were served as the control group. The levels of MMP-9 and TIMP-1, fasting blood glucose, total cholesterol, triglyceride and hypersensitive C-reactive protein were compared between the two groups. Results on the 1st day, the expression of MMP-9 gene in the experimental group was 1.73 times higher than that in the control group (1.03 脳 2.96), and the expression of MMP-9 gene on the 3rd day was 1.54 times higher than that in the control group (1.09 脳 2.92). On the 5th day, the expression of MMP-9 gene was 1.61 times higher than that of the control group (1.07 脳 3.09) (all P0.05). The level of TIMP-1 in the experimental group was significantly higher than that in the control group at the same time (P0.05). At the same time, there was a significant positive correlation between serum MMP-9 and TIMP-1 in the experimental group (all P0.05). Acute myocardial infarction combined with VF and hs-CRP (OR:1.742,95%CI:1.896~3.467), systolic blood pressure (OR:2.835,95%CI:1.896~3.467), Fasting blood glucose (OR:1.801,95%CI:1.436~2.347) was positively correlated. Conclusion there is a correlation between acute myocardial infarction (AMI) with VF and elevated serum MMP-9,TIMP-1 level, that is, high levels of MMP-9 and TIMP-1 are more likely to predict VF in patients with acute myocardial infarction (AMI).
【作者单位】：南昌大学第一附属医院急诊科;
【基金】：江西省科技厅科技支撑计划(2010BSA12500)
【分类号】：R542.22

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