重型颅脑创伤后患者血清甲状腺激素水平对病情严重程度及死亡率的影响

发布时间：2019-06-09 16:54

【摘要】：目的探讨重型颅脑创伤后患者血清甲状腺激素水平对病情严重程度及死亡率的影响。方法选取2013年1月-2015年1月在该院住院的重型颅脑创伤患者75例为观察组,另随机选取同期体检健康居民50例作为对照组,采用格拉斯哥昏迷评分(GCS)评估颅脑创伤严重程度,化学发光法检测血清甲状腺激素水平,计算住院患者死亡率,比较两组血清甲状腺激素水平差异,血清甲状腺激素水平对GCS评分、死亡率的影响。结果重型颅脑创伤患者血清(FT_3)、总甲状腺激素(TT_3)水平与对照组比较,差异有统计学意义(P0.05);重型颅脑创伤患者血清游离三碘甲状腺原氨酸(FT_3)、总甲状腺素(TT_3)水平与病情严重程度呈正相关(r=0.455和0.405,P=0.000);重型颅脑创伤患者血清FT_3、TT_3水平影响死亡率(P0.05)。结论重型颅脑创伤患者急性期甲状腺激素水平变化明显,血清FT_3、TT_3水平越低,病情越严重,死亡率越高。
[Abstract]:Objective to investigate the effect of serum thyroid hormone level on the severity and mortality of patients with severe craniocerebral trauma. Methods 75 patients with severe craniocerebral trauma hospitalized in our hospital from January 2013 to January 2015 were selected as the observation group, and 50 healthy residents were randomly selected as the control group. Glasgow coma score (GCS) was used to evaluate the severity of craniocerebral trauma, serum thyroid hormone levels were measured by chemiluminescence method, the mortality of inpatients was calculated, and the difference of serum thyroid hormone levels between the two groups was compared. Effect of serum thyroid hormone level on GCS score and mortality. Results the levels of serum (FT_3) and total thyroid hormone (TT_3) in patients with severe craniocerebral trauma were significantly different from those in the control group (P 0.05). The levels of serum free triiodothyronine (FT_3) and total thyroxine (TT_3) in patients with severe craniocerebral trauma were positively correlated with the severity of the disease (r 鈮，

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