替格瑞洛在急性前壁心肌梗死急诊经皮冠状动脉介入治疗中的应用
发布时间：2019-06-16 19:07
【摘要】：目的观察替格瑞洛在急性前壁心肌梗死患者急诊经皮冠状动脉介入治疗(PCI)中的抗血小板效果。方法将67例急性前壁心肌梗死行急诊PCI的患者随机分为替格瑞洛组和氯吡格雷组。两组入院后均接受其他常规治疗,氯吡格雷组术前给予氯吡格雷负荷剂量、术后给予氯吡格雷标准剂量口服治疗,替格瑞洛组术前给予替格瑞洛负荷剂量、术后给予替格瑞洛标准剂量口服治疗。比较两组血小板最大聚集率(MPAR)和血小板聚集抑制率(IPA)、手术前后TIMI血流分级及心脏彩超结果[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)]、术后6个月主要不良心血管事件及出血并发症。结果替格瑞洛组服药后1、2、24 h及服药后7 d MPAR低于氯吡格雷组,IPA高于氯吡格雷组(P均0.05);替格瑞洛组术后TIMI分级和LVEF高于氯吡格雷组,LVEDD低于氯吡格雷组(P均0.05)。替格瑞洛组主要不良心血管事件发生率低于氯吡格雷组(P0.05),两组出血并发症发生率无统计学差异。结论急诊PCI治疗急性前壁心肌梗死时,使用替格瑞洛抗血小板治疗效果较氯吡格雷更佳,安全性更高。
[Abstract]:Objective to observe the antiplatelet effect of tigrilol in emergency percutaneous coronary intervention (PCI) in patients with acute anterior myocardial infarction (ACMI). Methods 67 patients with acute anterior myocardial infarction undergoing emergency PCI were randomly divided into tegrilol group and clopidogrel group. Both groups received other routine treatment after admission. Clopidogrel group was given clopidogrel load dose before operation, clopidogrel standard dose after operation, tegrilol load dose before operation and tegrilol standard dose after operation. The maximum platelet aggregation rate (MPAR) and platelet aggregation inhibition rate (IPA),) before and after operation were compared between the two groups. TIMI blood flow classification and cardiac color Doppler ultrasound results [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD)], major adverse cardiovascular events and bleeding complications 6 months after operation. Results the MPAR of tigrilol group was lower than that of clopidogrel group at 1 h, 2 h, 24 h and 7 d after treatment, IPA was higher than that of clopidogrel group, TIMI grade and LVEF of tigrilol group were higher than those of clopidogrel group, and LVEDD was lower than that of clopidogrel group. The incidence of main adverse cardiovascular events in tigrilol group was lower than that in clopidogrel group (P 0.05). There was no significant difference in the incidence of bleeding complications between the two groups. Conclusion in the treatment of acute anterior myocardial infarction with emergency PCI, tigrilol is more effective and safe than clopidogrel in the treatment of acute anterior myocardial infarction.
【作者单位】： 安徽医科大学附属省立医院;马鞍山市人民医院;
【基金】：安徽省国际科技合作项目(0908703042)
【分类号】：R542.22
本文编号：2500760
[Abstract]:Objective to observe the antiplatelet effect of tigrilol in emergency percutaneous coronary intervention (PCI) in patients with acute anterior myocardial infarction (ACMI). Methods 67 patients with acute anterior myocardial infarction undergoing emergency PCI were randomly divided into tegrilol group and clopidogrel group. Both groups received other routine treatment after admission. Clopidogrel group was given clopidogrel load dose before operation, clopidogrel standard dose after operation, tegrilol load dose before operation and tegrilol standard dose after operation. The maximum platelet aggregation rate (MPAR) and platelet aggregation inhibition rate (IPA),) before and after operation were compared between the two groups. TIMI blood flow classification and cardiac color Doppler ultrasound results [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD)], major adverse cardiovascular events and bleeding complications 6 months after operation. Results the MPAR of tigrilol group was lower than that of clopidogrel group at 1 h, 2 h, 24 h and 7 d after treatment, IPA was higher than that of clopidogrel group, TIMI grade and LVEF of tigrilol group were higher than those of clopidogrel group, and LVEDD was lower than that of clopidogrel group. The incidence of main adverse cardiovascular events in tigrilol group was lower than that in clopidogrel group (P 0.05). There was no significant difference in the incidence of bleeding complications between the two groups. Conclusion in the treatment of acute anterior myocardial infarction with emergency PCI, tigrilol is more effective and safe than clopidogrel in the treatment of acute anterior myocardial infarction.
【作者单位】： 安徽医科大学附属省立医院;马鞍山市人民医院;
【基金】：安徽省国际科技合作项目(0908703042)
【分类号】：R542.22
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1 师树田;聂绍平;;替格瑞洛在急性冠状动脉综合征患者中的应用[J];中国介入心脏病学杂志;2014年07期
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