血清叶酸、维生素B12水平对急性缺血性脑卒中预后的影响

发布时间：2019-07-09 13:10

【摘要】：目的:探讨叶酸和维生素B12对急性缺血性脑卒中预后的影响。方法:选取急性缺血性脑卒中患者132例为观察组,健康体检者100例为对照组。采用改良Rankin量表评估,分为预后良好组(m RS0~2分)和预后不良好组(m RS 3~6分,其中6分代表死亡),分析入院时叶酸和维生素B12的水平及预后相关性。结果:急性缺血性脑卒中患者叶酸含量明显低于对照组[(5.84±2.83)ng/m L vs.(8.83±3.4)ng/m L,P0.001],维生素B12含量明显低于对照组[(444.61±254.08)pg/m L vs.(566.55±116.61)ng/m L,P0.001]。急性缺血性脑卒中患者预后不良组的叶酸含量低于预后良好组[(3.90±1.39)ng/m L vs.(6.42±2.89)ng/m L,P0.001],预后不良组的维生素B12含量明显低于预后良好组[(322.36±154.98)pg/m L vs.(480.56±266.62)pg/m L,P=0.002]。相关性分析显示叶酸及维生素B12与m RS均呈负相关(r=-0.447,P0.001;r=-0.231,P=0.008)。结论:叶酸和维生素B12是急性缺血性脑卒中潜在的预后评估标志物。
[Abstract]:Objective: to investigate the effect of folic acid and vitamin B 12 on the prognosis of acute ischemic stroke. Methods: 132 patients with acute ischemic stroke were selected as observation group and 100 healthy subjects as control group. The modified Rankin scale was used to evaluate the patients with good prognosis (m RS0~2 score) and poor prognosis group (m RS 3 ~ 6 points, in which 6 points represented death). The levels of folic acid and vitamin B12 at admission and the correlation between prognosis were analyzed. Results: the folic acid content in patients with acute ischemic stroke was significantly lower than that in the control group [(5.84 卤2.83) ng/m L vs. (8.83 卤3.4) ng/m / L, P0.001], and the vitamin B12 content in the control group was significantly lower than that in the control group [(444.61 卤254.08) pg/m L vs. (566.55 卤116.61 ng/m / L, P0.001]. The folic acid content in the poor prognosis group was lower than that in the good prognosis group [(3.90 卤1.39) ng/m L vs. (6.42 卤2.89) ng/m / L, P0.001]. The vitamin B12 content in the poor prognosis group was significantly lower than that in the good prognosis group [(322.36 卤154.98) pg/m L vs. (480.56 卤266.62 pg/m / L, P 鈮，

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