阿替普酶治疗急性脑梗死的疗效及对患者血清炎性因子的影响

发布时间：2019-07-12 17:43

【摘要】：目的探讨阿替普酶治疗急性脑梗死的疗效及其对患者血清炎性因子的影响。方法选择2011年5月至2014年5月来该院就诊急性脑梗死的患者120例,随机分成两组各60例。对照组患者采用常规的对症治疗。观察组患者在对照组治疗方式基础上加用阿替普酶治疗。结果观察组总有效率高于对照组(P0.01)。治疗后,观察组美国国立卫生研究院卒中量表(NIHSS)评分低于对照组(P0.01),Barthel评分高于对照组(P0.01),日常生活能力评分高于对照组(P0.05),交流、行动能力、思维、手部功能、力量高于对照组(P0.01),血清高敏C-反应蛋白(hs-CRP)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α都低于对照组(P0.01),IL~(-1)0水平高于对照组(P0.01)。结论阿替普酶用于治疗急性脑梗死疗效显著,可以有效地调节患者血清IL-6、hs-CRP、IL~(-1)0、TNF-α水平。
[Abstract]:Objective to investigate the efficacy of attepase in the treatment of acute cerebral infarction (ACI) and its effect on serum inflammatory factors. Methods 120 patients with acute cerebral infarction from May 2011 to May 2014 were randomly divided into two groups. The patients in the control group were treated with routine symptomatic treatment. The patients in the observation group were treated with atex on the basis of the treatment method of the control group. Results the total effective rate in the observation group was higher than that in the control group (P 0.01). After treatment, the (NIHSS) score of the National Institutes of Health Stroke scale in the observation group was lower than that in the control group (P01), Barthel score was higher than that in the control group (P01), the score of daily living ability was higher than that in the control group (P05), the communication, mobility, thinking, hand function, strength and strength were higher than those in the control group (P01). Serum high sensitivity C-reactive protein (hs-CRP), IL-6. Tumor necrosis factor (TNF)-伪 was lower than that of the control group (P 0.01), and the level of IL~ (- 1) 0 was higher than that of the control group (P 0.01). Conclusion Attipase is effective in the treatment of acute cerebral infarction and can effectively regulate the level of serum IL-6,hs-CRP,IL~ (- 1) and TNF-伪 in patients with acute cerebral infarction.
【作者单位】：东昌府人民医院神经内科;聊城市人民医院神经内科;
【基金】：国家十二五科技支撑计划(No.2011BAI08B02)
【分类号】：R743.3

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