血栓通注射液治疗颅外伤合并多发性肋骨骨折患者的临床研究

发布时间：2019-07-21 20:30

【摘要】：目的观察血栓通对颅外伤合并多发性肋骨骨折患者的临床疗效。方法 66例颅外伤合并多发性肋骨骨折患者随机分为对照组33例和试验组33例。2组均实施手术纠正及持续吸氧、降颅压、神经营养支持、纠正水电解质紊乱、对症治疗等治疗。试验组在此基础上,静脉滴注血栓通注射液5 m L,溶于5%葡萄糖溶液250 m L,每日1次,持续14 d。比较2组患者治疗前、治疗7,14 d后疼痛评分、血氧饱和度变化和神经功能缺损程度评分;根据患者病情分为Ⅰ、Ⅱ、Ⅲ级,比较各级患者呼吸机使用时间、止痛药使用时间及住院时间。结果治疗7,14 d后,试验组的疼痛视觉模拟评分(VAS)分别为(2.33±0.51),(1.20±0.38)分,对照组的VAS分别为(7.05±1.39),(2.81±0.40)分;试验组神经功能缺损程度评分量表(NDS)评分分别为(10.70±2.99),(8.06±3.38)分,对照组的NDS评分分别为(15.84±4.62),(11.29±2.58)分,差异有统计学意义(P0.05)。治疗7,14 d后,试验组的动脉血氧饱和度(SpO_2)分别为(90.36±3.55)%,(95.52±4.07)%;对照组的Sp O2分别为(89.81±3.42)%,(94.71±3.96)%,2组与治疗前相比,差异均有统计学意义(均P0.05)。试验组Ⅰ、Ⅱ、Ⅲ级患者呼吸机使用时间分别为0,(1.13±0.96),(4.02±3.70)d;对照组Ⅰ、Ⅱ、Ⅲ级患者呼吸机使用时间分别为0,(4.59±3.05),(7.96±6.13)d;试验组Ⅰ、Ⅱ、Ⅲ级患者止痛药使用时间分别为(2.09±0.58),(4.71±0.83),(7.09±1.25)d,对照组Ⅰ、Ⅱ、Ⅲ级患者止痛药使用时间分别为(4.31±1.07),(8.20±3.55),(13.26±5.81)d;试验组Ⅰ、Ⅱ、Ⅲ级患者住院时间分别为(10.69±3.75),(15.36±8.22),(18.31±5.07)d,对照组Ⅰ、Ⅱ、Ⅲ级患者住院时间分别为(17.26±3.58),(19.39±5.42),(30.05±2.44)d,2组差异有统计学意义(P0.05)。2组均未发生药物不良反应。结论血栓通能够有效改善颅外伤合并多发性肋骨骨折患者临床症状,促进其神经功能及机体状态的恢复,有助于缩短住院时间和止痛药物用量,对患者预后质量的改善具有积极作用。
[Abstract]:Objective To observe the clinical effect of thrombi on the patients with multiple rib fractures. Methods Sixty-six patients with multiple rib fractures were randomly divided into the control group (33 cases) and the test group (33 cases). On the basis of this, the group of 5% glucose solution was dissolved in 5% glucose solution for 14 days, and the scores of pain, blood oxygen saturation and the degree of neurological deficit were assessed before and after treatment for 7 and 14 days. According to the condition of the patient, the use time of the ventilator, the use time of the analgesic and the hospital stay time are compared. Results After 7 and 14 days of treatment, the visual analogue scores (VAS) of the test group were (2.33-0.51), (1.20-0.38), and the VAS of the control group was (7.05-1.39), (2.81-0.40), and the scores of the neurological deficit scores (NDS) in the test group were (10.70-2.99), respectively. (8.06-3.38), the NDS scores of the control group were (15.84-4.62), (11.29-2.58), and the difference was significant (P0.05). After 7 and 14 days, the arterial oxygen saturation (SpO _ 2) in the test group was (90.36-3.55)%, (95.52-4.07)%, respectively (89.81-3.42)%, (94.71-3.96)% in the control group, and the difference was statistically significant (P0.05). The use time of the ventilator was 0, (1.13, 0.96), (4.02, 3.70) d in the test group,0, (4.59, 3.05), (7.96 to 6.13) d in the control group, (7.96, 6.13) d, and the test groups I and II, respectively. The use time of the pain-relievers in stage 鈪，

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