遗忘型轻度认知障碍患者静息态脑功能网络局部一致性

发布时间：2017-12-27 11:22

本文关键词：遗忘型轻度认知障碍患者静息态脑功能网络局部一致性　出处：《中国老年学杂志》2015年22期 　论文类型：期刊论文

【摘要】：目的利用功能磁共振成像(f MRI)技术探讨遗忘型轻度认知障碍(a MCI)患者静息态脑活动神经网络结构和功能特点。方法分别对根据临床诊断的10例a MCI患者及10例健康志愿者进行静息态功能磁共振扫描,利用脑功能网络局部一致性(Re Ho)分析方法,比较a MCI患者与健康志愿者静息态下大脑活动差异。结果 a MCI患者Re Ho分析显示后扣带回区域、额叶内侧、前额叶内侧皮层和顶叶部分区域的Re Ho均显著增高。a MCI患者左侧颞叶(颞中回、颞下回)、左侧海马旁回、枕叶、舌回、楔前叶等区域的Re Ho降低,而右侧额叶(额下回)、左颞上回、中央前回(额叶)、右侧丘脑、左侧梭状回等区域的Re Ho增高。结论静息状态下,a MCI患者可能存在着局部脑区功能异常,这种异常与认知功能减退可能存在一定联系。
[Abstract]:Objective to explore the structure and function of resting brain active neural network in patients with amnestic mild cognitive impairment (a MCI) by functional magnetic resonance imaging (f MRI). Methods 10 patients with a MCI and 10 healthy volunteers were examined by resting state functional magnetic resonance imaging (fMRI). The difference of brain activity in resting state between a MCI patients and healthy volunteers was compared by using Re Ho method. Results the Re Ho analysis of patients with a MCI showed that the Re Ho in the cingulate gyrus, the medial frontal lobes, the medial prefrontal cortex and the parietal lobe were all significantly higher. The Re Ho in the left temporal lobe (middle temporal gyrus, inferior temporal gyrus), left parahippocampal gyrus, occipital lobe, lingual gyrus and prefrontal lobe decreased in a MCI patients, while the Re Ho in the right E Ye (inferior frontal gyrus), left superior temporal gyrus, central anterior gyrus (E Ye), right thalamus and left fusiform gyrus increased. Conclusion in resting state, the patients with a MCI may have abnormal regional brain function, which may be associated with cognitive impairment.
【作者单位】：南昌市第一医院;南昌航空大学;南昌大学第二附属医院神经内科;
【分类号】：R749.16
【正文快照】： 1南昌市第一医院2南昌航空大学阿尔茨海默病(AD)作为老年痴呆最常见的原因,以渐进性记忆力丧失为特点,逐渐累及患者认知及其他非认知功能。遗忘型轻度认知障碍(a MCI)以情节记忆障碍为突出表现,a M-CI向AD的年转化率是正常人群的10倍。因此a MCI被认为是AD的前驱阶段,如能在此

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