美金刚在重庆地区痴呆患者中的用药现况调查

发布时间：2017-12-28 06:37

本文关键词：美金刚在重庆地区痴呆患者中的用药现况调查　出处：《重庆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：背景：痴呆是一种常见的神经退性疾病。随着人均寿命延长,患痴呆的风险率增加,给社会及家庭带来沉重负担。美金刚是目前主要用于治疗痴呆的药物。自2010年美金刚被列入重庆医保药品,在我区才逐渐被应用。但临床中发现很多患者不能坚持使用美金刚,因此有必要对目前美金刚使用现况进行调查。目的：美金刚于2006年在中国上市,其主要适用于中度或重度阿尔茨海默病患者(Alzheimer's disease, AD)。然而,在重庆地区抗痴呆治疗并不广泛,为进一步了解痴呆治疗现况,本研究调查了我院美金刚的使用情况。方法：本研究开展于2011.1-2015.3期间,资料来源于重庆医科大学附属第一医院药物数据库及老年病科记忆障碍门诊。主要通过门诊及电话随访的方式收集相关信息,包括患者基本信息、美金刚用药剂量、疗效、副作用、临床疗效总评法(clinical global impression change, CGI-C)及停药原因。统计分析采用SPSS statistics 17.0软件完成,检验水平为a=0.05,一般资料采用描述性统计分析,非正态分布计量资料用Man-Whitney U检验。主要结果：本次调查中共收集了159名患者的信息,122名患者完成了这项研究。其中42名患者使用美金刚时间小于1月,23名患者使用时间在1月至6月之间,57名患者使用美金刚时间超过6个月。停用美金刚的原因主要包括：缺乏对痴呆患者照料的知识、经济原因、不满意疗效、明显的副作用。服用美金刚时间大于6个月患者比小于1月的患者CGI-C评分有统计学差异(CGI-C score 3.94 vs.4.44,p0.05).本项调查中,共有5人出现副作用。结论：本次调查显示美金刚的临床应用基本合理,但是患者的用药依从性不高。调查结果有助于推行公众教育活动,提高公众对老年痴呆的认识。
[Abstract]:Background: dementia is a common neurodegenerative disease. As the per capita life span is prolonged, the risk rate of dementia increases and brings a heavy burden to the society and the family. Memantine is currently mainly used in medicine for treating dementia. Since 2010, memantine was included in the Chongqing medical insurance drugs, in my area have gradually been applied. But the clinical found that many patients can not adhere to the use of memantine, so it is necessary to survey on the status of the use of memantine. Objective: to China memantine listed in 2006, which is mainly suitable for patients with moderate or severe Alzheimer's disease (Alzheimer's, disease, AD). However, in the Chongqing area of anti dementia treatment is not widely, in order to further understand the treatment status of dementia, this study investigated the use of memantine in our hospital. Methods: the study was conducted during the period of 2011.1-2015.3, and the data were derived from the First Affiliated Hospital of Chongqing Medical University drug database and the memory disorder clinic in the Department of geriatrics. Collect relevant information mainly through outpatient and telephone follow-up, including the basic information of the patients, the clinical curative effect of memantine dosage, efficacy, side effects and evaluation method (clinical global impression change, CGI-C) and the cause of the withdrawal. Statistical analysis was completed by SPSS statistics 17 software. The test level was a=0.05. The general data were analyzed by descriptive statistics, and the non normal distribution data were tested by Man-Whitney U. Main results: a total of 159 patients were collected in this survey, and 122 patients completed the study. 42 of the patients used memantine time of less than January, 23 patients with time between January and June, 57 patients with memantine for more than 6 months. The reasons for discontinuation of memantine mainly include: lack of side effects on patients with dementia care knowledge and economic reasons, not satisfactory curative effect, obvious. Take time more than 6 months in patients with memantine score had significant difference less than January in patients with CGI-C (CGI-C score 3.94 vs.4.44, P0.05). In this survey, a total of 5 people have side effects. Conclusion: the survey showed that the clinical application of memantine is basically reasonable, but the medication compliance of patients is not high. The findings are helpful in promoting public education activities and raising public awareness of Alzheimer's disease.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R749.16

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