首发精神分裂症幻听患者及精神分裂症患者一级亲属的脑功能磁共振研究

发布时间：2017-12-31 04:33

本文关键词：首发精神分裂症幻听患者及精神分裂症患者一级亲属的脑功能磁共振研究　出处：《第四军医大学》2016年硕士论文　论文类型：学位论文

【摘要】：实验一首发精神分裂症幻听患者的全脑白质变化研究目的:探讨首发精神分裂症幻听患者的全脑白质纤维精细结构的改变。方法:分别对25例首发精神分裂症幻听患者和25例正常对照行扩散张量成像序列扫描,采用基于纤维束示踪的空间统计分析方法分析两组被试全脑各向异性分数,使用非参数的随机排列检验对两组人群全脑DTI序列所得到的FA值进行统计分析比较,继而得出有差异的脑区。结果:与正常组相比,首发精神分裂幻听组左侧额眶回与顶下小叶的白质FA值明显降低,差异具有统计学意义(P0.05)。结论:TBSS方法能较全面、准确地分析首发精神分裂症幻听患者早期脑白质纤维精细结构的改变。实验证明了首发精神分裂症幻听患者的全脑白质纤维束异常区域,这些异常可能是精神分裂症幻听患者发生发展的神经生物学基础。实验二精神分裂症患者一级亲属的静息态脑功能研究目的:家族易感性风险在精神分裂症的发病中起着非常重要的作用。许多精神分裂症家属的神经影像学研究显示了其结构与功能的异常改变,其中这些异常改变主要位于前扣带回、背外侧前额叶、海马、尾状核。本研究纳入未患病精神分裂症患者一级亲属及正常对照,选择双侧前扣带回、左侧背外侧前额叶、双侧海马、双侧尾状核作为感兴趣区并使用有效连接的方法来探讨他们之间静息态连接的不同。方法:研究对象包括46名精神分裂症患者一级亲属(患者均经美国精神疾病诊断与统计第四版来诊断)与50名健康对照,所以被试均经过静息态功能磁共振扫描,使用随机动态因果建模的方法来估计上述7个感兴趣区之间的连接强度,从有效连接的角度使用贝叶斯参数平均模型来研究受试者脑神经网络的变化,结果:BPA结果显示精神分裂症患者家属组从前扣带到海马之间的有效连接与正常对照组之间存在差异。结论:前扣带到海马之间的失连接可能是精神分裂症发生的高危因素,这也可能是精神分裂症家族易感性的原因之一。
[Abstract]:Study on the changes of whole brain white matter in patients with first episode schizophrenia auditory hallucination objective: to investigate the changes of the fine structure of white matter fibers in patients with first episode schizophrenia auditory hallucinations. Diffusion Zhang Liang imaging sequence was performed in 25 patients with first episode schizophrenia and 25 normal controls. The anisotropy fraction of the whole brain of the two groups was analyzed by using the spatial statistical analysis method based on the tracer of fiber bundle. The FA values obtained from the whole brain DTI sequence of the two groups were statistically analyzed and compared using non-parametric random arrangement test, and then the different brain regions were obtained. Results: compared with the normal group. The FA value of the left frontal orbital gyrus and inferior parietal lobule in the first episode group was significantly lower than that in the control group (P 0.05). The changes of the fine structure of white matter fiber in the early stage of the first episode schizophrenia were analyzed accurately. The experiment proved that the abnormal area of the white matter fiber bundle of the whole brain in the first episode schizophrenic auditory hallucination patients. These abnormalities may be the neurobiological basis for the development of auditory hallucinations in schizophrenic patients. Family susceptibility risk plays a very important role in the pathogenesis of schizophrenia. Many neuroimaging studies of family members of schizophrenia show abnormal structural and functional changes. These abnormal changes were mainly located in anterior cingulate gyrus, dorsolateral prefrontal lobe, hippocampus, caudate nucleus. Left dorsolateral prefrontal lobe, bilateral hippocampus. The bilateral caudate nucleus was used as the region of interest and the effective connection method was used to explore the differences of resting connections between them. Methods: the subjects included 46 first-degree relatives of patients with schizophrenia. All patients were diagnosed by the US Psychiatric Diagnostic and Statistical Edition 4th) and 50 healthy controls. So all the subjects were scanned by resting functional magnetic resonance (fMRI) and the connection strength between the seven regions of interest was estimated by using random dynamic causality modeling method. Bayesian parametric averaging model is used to study the changes of neural networks in subjects from the point of view of effective connection. Results the results of BPA showed that the effective connection between the former buckle and the hippocampus of the schizophrenic family group was different from that of the normal control group. The loss of connection between the anterior buckles and the hippocampus may be a risk factor for schizophrenia. This may also be one of the reasons for the susceptibility of schizophrenia families.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R749.3;R445.2

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