舍曲林联合心理疗法治疗青少年强迫症的临床疗效及安全性评价

发布时间：2017-12-31 09:37

本文关键词：舍曲林联合心理疗法治疗青少年强迫症的临床疗效及安全性评价　出处：《中国临床药理学杂志》2015年19期 　论文类型：期刊论文

更多相关文章： 舍曲林 心理治疗 青少年 强迫症

【摘要】：目的评价舍曲林联合心理疗法治疗青少年强迫症的临床疗效及安全性。方法 110例青少年强迫症患者随机分为试验组及对照组,各55例。2组均给予舍曲林治疗,每次50~100 mg,持续12周;试验组在此基础上接受心理治疗。比较2组患者的临床疗效。结果试验组总有效率为85.5%,对照组为63.6%,试验组显著高于对照组(P0.05)。2组患者治疗后耶鲁布朗强迫量表评分、汉密尔顿焦虑量表评分均显著降低,试验组降低更为明显(P0.05)。2组患者治疗期间副反应量表评分均未见明显变化(P0.05),试验组治疗期间副反应量表评分显著低于对照组(P0.05)。结论舍曲林联合心理治疗能够明显改善青少年强迫症患者临床症状,且可减轻治疗不良反应,具有良好的疗效及安全性。
[Abstract]:Objective to evaluate the clinical efficacy and safety of sertraline combined with psychotherapy in the treatment of adolescent obsessive-compulsive disorder (OCD). Methods 110 adolescent OCD patients were randomly divided into experimental group and control group. Each group (55 cases) was treated with sertraline for 12 weeks with 50 mg of sertraline for 12 weeks. On this basis, the experimental group received psychological treatment. The clinical efficacy of the two groups was compared. Results the total effective rate of the trial group was 85.5 and that of the control group was 63.6%. The scores of Yale Brown obsessive compulsion scale and Hamilton anxiety scale were significantly lower in the trial group than in the control group. There was no significant change in the score of side effects scale during treatment in the trial group (P 0.05). The scores of side effects in the trial group were significantly lower than those in the control group (P 0.05). Conclusion Sertraline combined with psychotherapy can significantly improve the clinical symptoms of adolescent obsessive-compulsive disorder patients and alleviate the adverse effects of treatment. It has good curative effect and safety.
【作者单位】：第三军医大学卫生勤务学教研室;空军都江堰航空医学鉴定训练中心;成都军区空军司令部门诊部;
【基金】：军队心理卫生科研面上课题基金资助项目(12XLZ334)
【分类号】：R749
【正文快照】： 方海亮1,郝枭雄1,陈统2,代康3,黄朝晖1(1.第三军医大学卫生勤务学教研室,重庆400038;2.空军都江堰航空医学鉴定训练中心,四川都江堰611830;3.成都军区空军司令部门诊部,成都610041)FANG Hai-Liang1,HAO Xiao-Xiong1,CHEN Tong2,DAI Kang3,HUANG Zhao-Hui1(1.Department of Hea

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