2型糖尿病患者血清脂联素水平与其抑郁症状的影响因素分析

发布时间：2018-01-01 00:34

本文关键词：2型糖尿病患者血清脂联素水平与其抑郁症状的影响因素分析　出处：《中国现代医学杂志》2016年13期 　论文类型：期刊论文

【摘要】：目的探讨2型糖尿病(T2DM)患者血清脂联素(APN)水平与其抑郁症状的相关性。方法选取唐山市工人医院住院的T2DM患者523例作为研究对象。记录患者的年龄、性别、教育、体重指数(BMI)、病程。收集其临床检验结果,包括空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、总胆固醇(TC)、三酰甘油(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP),酶联免疫吸附法(ELISA)法测定血清APN水平。用抑郁自评量表(SDS)对患者的抑郁症状进行评定,根据SDS评定结果将患者分为伴抑郁组和不伴抑郁组。结果①T2DM患者抑郁的患病率为36.7%,轻度抑郁患病率为27.5%,中度抑郁患病率为7.3%,重度抑郁患病率为1.9%;②与不伴抑郁组比较,伴抑郁组患者病程较长,BMI、Hb A1c、TG、Hcy、hs-CRP水平较高,而APN水平较低(P0.05);③HDL(b=0.452,P=0.000)、TG(b=-0.036,P=0.018)、Hb A1c(b=-0.114,P=0.012)是APN的影响因素;④APN(b=-3.128,P=0.000)、Hcy(b=0.237,P=0.002)、病程(b=0.243,P=0.004)、Hb A1c(b=0.645,P=0.018)是SDS评分的影响因素。结论 T2DM患者血清APN水平降低可能是其出现抑郁症状的危险因素之一。
[Abstract]:Objective to study the serum adiponectin (APN) in patients with type 2 diabetes mellitus (T2DM). Methods 523 T2DM patients hospitalized in workers' hospital of Tangshan City were selected as the study subjects. The age of the patients was recorded. Sex, education, body mass index (BMI), course of disease. Clinical test results were collected, including fasting blood glucose (FBG) FPGG, HbA1cU (glycosylated hemoglobin), total cholesterol (TC3). Triacylglycerol (TCN), high density lipoprotein (HDL), low density lipoprotein (LDL), homocysteine (Hcyn), hypersensitive C-reactive protein (hs-CRP). The serum APN level was measured by Elisa and the depressive symptoms were assessed by self-rating depression scale (SDS). According to the results of SDS, the patients were divided into depression group and non-depression group. Results 1the prevalence of depression in T2DM patients was 36.7%, and the prevalence rate of mild depression was 27.5%. The prevalence of moderate depression was 7.3 and that of severe depression was 1.9. 2Compared with the group without depression, the patients with depression had a longer course of disease, the level of Hcyhs-CRP was higher and the level of APN was lower than that of P0.05in the patients with depression. (3) HbA1 (HbA1), HbA1C, BX (0.114), TGG BU (0.036), PU (0.018), and HbA1cPU (0.114). P0. 012) is the influencing factor of APN. (4) APN BU -3.128A (0.000), Hcy (0.237) (P ~ (0.002)), course of disease (0.243) (P ~ (0.004)). HB A _ 1C _ (1) C ~ (1) B ~ (2 +) 0.645. Conclusion the decrease of serum APN level may be one of the risk factors for depression in patients with T2DM.
【作者单位】：河北省唐山市工人医院内分泌二科;
【分类号】：R587.1;R749.4
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