催产素对大鼠创伤后应激障碍的预防作用

发布时间：2018-01-01 15:22

本文关键词：催产素对大鼠创伤后应激障碍的预防作用　出处：《山东医药》2015年41期 　论文类型：期刊论文

【摘要】：目的探讨催产素对大鼠创伤后应激障碍(PTSD)的影响。方法将Wistar大鼠24只随机分为空白对照组、单纯应激组、催产素组各8只。单纯应激组、催产素组给予大鼠单次延长应激(SPS)刺激,其中催产素组在应激后12 h内给予催产素干预,共干预14 d。干预过程中每隔3 d评价各组拒缚反射评分;干预第16天各组给予旷场实验,观察其穿格行为和站立行为;第17~21天行Morris水迷宫实验,观察其定位航行能力、空间探索能力。结果与单纯应激组比较,催产素组拒缚反射评分降低,旷场实验穿格次数和站立次数增多,定位航行能力及空间探索能力改善,两组比较差异均有统计学意义(P均0.05)。结论应激后早期及时给予催产素干预可明显减轻大鼠的应激相关表现,并且对应激造成大鼠的学习记忆能力损伤有保护作用。
[Abstract]:Objective to investigate oxytocin in rats with posttraumatic stress disorder (PTSD) effect. Methods 24 Wistar rats were randomly divided into control group, stress group, oxytocin group with 8 rats in each group. Stress group, oxytocin group rats were given single prolonged stress (SPS) stimulation, including oxytocin in the group given oxytocin 12 h after stress hormone intervention, intervention every 14 d. during the intervention 3 D were evaluated to bound reflection score; intervention groups were given sixteenth days of open field experiment, to observe the wear behavior and lattice standing behavior; the 17~21 days Morris water maze test, observe its navigation ability, space exploration ability results compared with stress group, oxytocin group to bind reflex decreased, open field test and the number of crossing line stand number increase, navigation ability and space exploration ability improved, with significant differences between the two groups (P < 0.05). Conclusion early and after stress The intervention of oxytocin could significantly reduce the stress related performance of rats and protect the learning and memory impairment of rats.

【作者单位】：石河子大学医学院;石河子大学医学院第一附属医院;
【基金】：“十二五”新疆生产建设兵团医药卫生重点领域科技攻关项目(2012BA023)
【分类号】：R749.5
【正文快照】： 创伤后应激障碍(PTSD)临床症状主要包括病理性重现创伤事件、警觉性增高、学习记忆能力下降等[1],均可对健康产生不良影响[2]。近年来,越来越多的研究表明,催产素在社会行为中发挥重要调节作用[3];受试对象在遭受应激但还未出现PTSD症状时,及时给予催产素进行干预能否取得预防

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