强迫障碍患者静息态脑功能网络节点中心度的异常

发布时间：2018-01-01 23:18

本文关键词：强迫障碍患者静息态脑功能网络节点中心度的异常　出处：《中国心理卫生杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的:应用基于体素的节点中心度(degree centrality,DC)方法探讨强迫障碍患者静息态下脑功能网络连接属性的改变。方法:纳入符合美国精神障碍诊断与统计手册第4版修订版(DSM-IVTR)强迫障碍诊断标准的30例门诊和住院患者,以及30名性别、年龄和受教育程度相匹配的健康对照。采用耶鲁-布郎强迫量表、汉密顿抑郁量表、汉密顿焦虑量表评估强迫障碍患者强迫思维和强迫行为以及抑郁焦虑症状。所有被试进行全脑静息态功能磁共振成像扫描,采用DPARSFA分析软件计算被试的DC值。结果:与正常对照相比,强迫障碍患者右侧眶额回[(-0.22±0.45)vs.(-0.57±0.22)]和左侧前扣带回[(0.14±0.48)vs.(-0.21±0.33)]的DC值升高(P0.001);右侧岛叶的DC值降低[(-0.12±0.37)vs.(0.35±0.54)](P0.001);右侧眶额回的DC值与耶鲁-布郎强迫量表总分正相关(r=0.68,P0.05)。结论:静息状态下,大脑执行控制网络和突显网络重要节点/脑区连接属性的异常可能与强迫障碍的病理生理机制有关。
[Abstract]:Objective: Based on node center voxel degree (degree centrality DC) method to investigate the brain functional network during resting state in patients with obsessive-compulsive disorder with attribute changes. Methods: Patients accorded with the diagnostic and Statistical Manual of mental disorders Fourth Edition (DSM-IVTR) 30 cases of obsessive-compulsive disorder diagnostic criteria and patients, as well as 30 sex, age and education matched healthy controls. The Yale Brown Obsessive Compulsive Scale, Hamilton Depression Scale, Hamilton Anxiety Scale Evaluation in patients with obsessive-compulsive disorder, obsessive and compulsive symptoms of depression and anxiety. All of the subjects were the whole brain resting state functional magnetic resonance imaging scans were calculated by DPARSFA analysis test software DC. Results: compared with normal controls, patients with obsessive-compulsive disorder right orbitofrontal gyrus [(-0.22 + 0.45) vs. (-0.57 + 0.22) and left anterior cingulate [(0.14 + 0.48 + 0.33 (-0.21) vs. )] increased DC (P0.001); right insula DC decreased [(-0.12 + 0.37) vs. (0.35 + 0.54)] (P0.001); the right orbitofrontal gyrus DC score was positively correlated with Yale Brown obsessive amount (r=0.68, P0.05). Conclusion: the resting state, the pathophysiology of obsessive-compulsive disorder and abnormal brain Executive control network and network node / brain region important highlight the properties of the connection.

【作者单位】：齐齐哈尔医学院精神卫生学院临床心理教研室;齐齐哈尔医学院精神卫生学院精神医学教研室;齐齐哈尔医学院第三附属医院磁共振科;齐齐哈尔市精神卫生中心临床心理科;齐齐哈尔医学院第四附属医院开放病区;
【基金】：黑龙江省教育厅科学技术研究项目——SLC1A1基因rs301430多态性对强迫障碍静息态脑功能影响的研究(12541904)
【分类号】：R749.7;R445.2
【正文快照】： 强迫障碍(obsessive-compulsive disorder,tion,text Revision,DSM-IV-TR)中强迫障碍的OCD)是临床上常见且难以治愈的精神障碍之一,诊断标准[7];(2)耶鲁-布郎强迫量表(Yale-在普通人群中的终生患病率约为2%~3%,全球Brow n Obsessive-Compulsive Scale,Y-BOCS[8]总约有5000万人

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