利培酮治疗额颞脑挫裂伤后精神症状的临床研究

发布时间：2018-01-02 15:03

本文关键词：利培酮治疗额颞脑挫裂伤后精神症状的临床研究　出处：《中国神经精神疾病杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的观察利培酮在额颞脑挫裂伤后精神症状临床治疗中的疗效。方法选取2009年1月至2011年12月期间我院收治的60例额颞脑挫裂伤后伴有精神症状患者作为观察对象,随机分为对照组和治疗组,对照组患者给予维生素B160mg/d,治疗组患者给予利培酮1mg/d,2组疗程均为1个月,分别于治疗前、后使用阳性与阴性症状量表(PANSS)与症状量表(TESS)对两组患者的治疗效果及不良反应进行评价,对结果进行对比分析。结果治疗组治疗开始后第1、2、3、4周的PANSS评分明显低于对照组,两组对比差异具有统计学意义(F=48.12,P0.0001),时间对比差异具有统计学意义(F=290.99,P0.0001),组间与时间交互作用具有统计学意义(F=11.91,P0.0001)。经控制时间点后两组比较具体表现为治疗开始后第1、2、3、4周两组对比差异具有统计学意义。治疗过程中两组患者均出现不同程度的头痛、反胃、体重增加以及心动过速等不良反应,均经对症处理后明显缓解。结论利培酮可明显改善患者额颞脑挫裂伤后精神症状,安全有效。
[Abstract]:Objective To observe the clinical curative effect of risperidone in the treatment of psychiatric symptoms of frontotemporal brain contusion after. Methods from January 2009 to December 2011 during the 60 cases of frontotemporal brain contusion and laceration in our hospital after the patients accompanied by mental symptoms as observation objects, and were randomly divided into control group and treatment group, the control group were treated with vitamin B160mg/d, patients in the treatment group were given in 1mg/d, the 2 groups were treated for 1 months, respectively before treatment, after the use of positive and negative symptom scale (PANSS) and symptom scale (TESS) and to evaluate the adverse reactions of two groups of patients, the results were compared. Results: patients in the treatment group after the start of the week 1,2,3,4 the PANSS score was significantly lower than the control group, with significant difference between the two groups (F=48.12, P0.0001), statistically significant time differences (F=290.99, P0.0001), and the interaction time between the groups was statistically The significance of (F=11.91, P0.0001). By controlling the time points after the two groups for specific performance was statistically significant after treatment began at 1,2,3,4 weeks. The differences between the two groups during the treatment of two groups of patients showed varying degrees of headache, nausea, weight gain and bradycardia adverse reaction rate, were relieved after symptomatic treatment conclusion risperidone can significantly improve patients with frontotemporal brain contusion after psychiatric symptoms, is safe and effective.

【作者单位】：吉林省长春市一汽总医院神经外科;
【分类号】：R749.3
【正文快照】： ??吉林省长春市一汽总医院神经外科(长春130011)精神障碍常见于脑器质性损伤,脑挫裂伤后患者出现精神障碍要比发生脑震荡、脑干损伤以及头皮外伤患者发生精神障碍多[1]。研究显示[2]脑挫裂伤后精神症状与颅脑损伤的部位紧密相关, 额叶和颞叶损伤之后经常会继发精神障碍。本文

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