双相情感障碍躁狂相患者糖脂代谢相关因素分析

发布时间：2018-01-04 09:46

本文关键词：双相情感障碍躁狂相患者糖脂代谢相关因素分析　出处：《上海交通大学学报(医学版)》2015年10期 　论文类型：期刊论文

【摘要】：目的了解双相障碍患者糖脂代谢状况并探索相关影响因素。方法应用双相躁狂疾病路径调查问卷(BIPAS)筛选3 906例双相障碍患者,在本研究中入组2 229例患者。结果患者的糖脂代谢指标明显异常,三酰甘油、高密度脂蛋白、低密度脂蛋白水平与性别有关(P0.05);不同临床相(首次发作期、复发期和稳定期)患者的三酰甘油、低密度脂蛋白及空腹血糖水平的差异有统计学意义(P0.05);接受不同药物治疗方案(心境稳定剂联合抗精神病药物与心境稳定剂联合非抗精神病药物)患者间的三酰甘油水平的差异有统计学意义(P0.05);不同病程、首次发作类型及疾病发作次数的患者糖脂代谢水平的差异有统计学意义(P0.05)。结论双相障碍患者的糖脂代谢指标明显紊乱,且相关指标的差异与患者的性别、双相障碍的临床相、治疗方案及病程、首发病类型及发病次数有关。
[Abstract]:Objective to understand the status of patients with bipolar disorder of glucose and lipid metabolism and explore the related factors. Methods bipolar manic disease path questionnaire (BIPAS) screening of 3906 cases of patients with bipolar disorder, 2229 patients were enrolled in this study. The results of glucose and lipid metabolism in patients with abnormal three, triglyceride, high density lipoprotein, low density lipoprotein level and gender (P0.05); different clinical phase (first exacerbation, recurrence period and stable period) with three glycerol, there were statistically significant differences in low density lipoprotein and fasting blood glucose level (P0.05); received different therapeutic schemes (mood stabilizers and antipsychotics and mood stabilizers combined with non antipsychotic drugs) were statistically significant differences between patients three triglyceride level (P0.05); different course, different types and levels of glucose and lipid metabolism in patients with the first onset of disease episodes are Statistical significance (P0.05). Conclusion glucose and lipid metabolism indexes in patients with bipolar disorder are significantly disorder, and the difference between the relevant indicators is related to the gender of patients, the clinical phase of bipolar disorder, the treatment plan and the course of disease, the type of onset and the number of times.

【作者单位】：上海交通大学医学院附属精神卫生中心心境障碍科;上海市虹口区精神卫生中心;
【基金】：科技部“十二五”国家科技支撑项目(2012BAI01B04) 上海市重性精神病重点实验室项目(13dz2260500) 国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873) 国家自然科学基金青年科学基金项目(81201056,81301159) 上海市精神卫生中心院级国际合作课题(2013-YJGJ-06)~~
【分类号】：R749.4
【正文快照】： 双相障碍在人群中的发病率约为3.5%,以反复静/抗焦虑药物、中药/中成药。5精神疾病家族史。发作的抑郁与情绪高涨为主要特征[1],由于该病的6实验室检查:包括血糖、血脂、内分泌激素等,所有自杀未遂风险明显高于其他精神疾病[2]而越来越受患者均空腹至少8 h抽取血样,经全自动分

【参考文献】