西酞普兰治疗肺癌术后抑郁症的临床观察

发布时间：2018-01-09 22:33

本文关键词：西酞普兰治疗肺癌术后抑郁症的临床观察　出处：《中国药房》2016年17期 　论文类型：期刊论文

【摘要】：目的:观察西酞普兰治疗肺癌术后抑郁症的临床疗效及安全性。方法:选取肺癌术后伴发抑郁症的患者114例,按随机数字表法分为观察组和对照组,各57例。对照组患者术后给予营养支持、平衡电解质等常规治疗,未服用抗抑郁药物;观察组患者术后口服氢溴酸西酞普兰片20 mg,qd。两组患者均连续治疗6周。观察两组患者临床疗效及治疗前后汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、健康调查量表(SF-36)评分,并记录不良反应发生情况。结果:观察组总有效率为87.72%,显著高于对照组的71.93%,差异有统计学意义(P0.05);两组患者治疗前HAMD评分、HAMA评分及SF-36各项评分和总分比较,差异无统计学意义(P0.05);两组患者治疗后HAMA评分、HAMD评分显著降低,且观察组显著低于对照组,SF-36各项评分和总分显著升高,且观察组显著高于对照组,差异均有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:西酞普兰治疗肺癌术后抑郁症的疗效显著,能明显改善患者精神状态和生存质量,且安全性较好。
[Abstract]:Objective: To observe the clinical efficacy and safety of citalopram in the treatment of lung cancer postoperative depression. Methods: 114 cases of patients with lung cancer postoperative depression, were randomly divided into observation group and control group, 57 cases each. The patients in the control group were given nutritional support, electrolyte balance and other conventional treatment. Not taking antidepressant drugs; the patients in the observation group after oral administration of Citalopram Hydrobromide Tablets 20 mg, qd. two groups of patients were treated for 6 weeks. Observe two groups of patients before and after treatment of the Hamilton Depression Scale (HAMD) score, Hamilton Anxiety Scale (HAMA) score, health survey scale (SF-36) score, and record the occurrence of adverse reactions. Results: the total effective rate of observation group was 87.72%, significantly higher than 71.93% in the control group, the difference was statistically significant (P0.05); the HAMD scores of two groups of patients, HAMA score and SF-36 score and total score difference. With no significant difference (P0.05); the two groups of patients after treatment HAMA score, HAMD score decreased significantly, and the observation group was significantly lower than the control group, the SF-36 score and total score were significantly increased, and the observation group was significantly higher than the control group, the differences were statistically significant (P0.05). Two groups of patients had no obvious adverse reactions. Conclusion: the efficacy of citalopram in the treatment of lung cancer postoperative depression significantly, can significantly improve the quality of life and mental state of the patients with good safety.

【作者单位】：河北大学附属医院胸外科;河北省精神卫生中心情感障碍科;
【分类号】：R734.2;R749.4
【正文快照】： 肺癌是临床常见的恶性肿瘤之一。流行病学调查研究显示,肺癌发病率、死亡率呈逐年上升趋势,且治疗方法仍无突破性进展,肺癌已成为当今世界死亡率最高的恶性肿瘤[1-2]。目前,以手术为主的综合疗法是其最主要的治疗手段,但术后不少患者出现不同程度的抑郁,严重影响了患者的生存

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