大脑胰岛素信号通路与葡萄糖代谢在阿尔茨海默病中的作用与关系

发布时间：2018-01-10 14:08

本文关键词：大脑胰岛素信号通路与葡萄糖代谢在阿尔茨海默病中的作用与关系　出处：《国际药学研究杂志》2016年01期 　论文类型：期刊论文

【摘要】：阿尔茨海默病(Alzheimer′s diseases,AD)是一种缓慢发展的神经退行性疾病,尽管对AD的研究已达百余年,但其确切的发病机制尚不清楚,也缺乏有效的治疗药物。近几十年研究发现,AD患者伴随着大脑胰岛素信号通路障碍以及大脑葡萄糖代谢紊乱。因此,有研究者认为胰岛素信号通路及大脑葡萄糖代谢稳态在AD中起着重要作用,甚至有提出AD是"3型糖尿病"的假说。本文将着重讨论大脑内胰岛素信号通路、葡萄糖代谢过程以及二者与AD的关系,以及基于胰岛素通路的AD防治药物的研究进展。
[Abstract]:Alzheimer's disease (AD) is a slowly developing neurodegenerative disease, although AD has been studied for more than 100 years. However, the exact pathogenesis of AD is not clear, and there is a lack of effective treatment drugs. In recent decades, it has been found that AD patients are accompanied by cerebral insulin signal pathway dysfunction and cerebral glucose metabolism disorder. Some researchers believe that insulin signaling pathway and cerebral glucose homeostasis play an important role in AD. There is even a hypothesis that AD is type 3 diabetes. This article will focus on the insulin signaling pathway in the brain, glucose metabolism and the relationship between the two and AD. And the research progress of AD prevention and cure drugs based on insulin pathway.
【作者单位】：军事医学科学院毒物药物研究所中药和神经免疫药理研究室抗毒药物与毒理学国家重点实验室;
【基金】：国家自然科学基金资助项目(81202505;81302759)
【分类号】：R749.16
【正文快照】： 几乎所有类型的细胞都能够对胰岛素产生反应。其中肝、肌肉和脂肪组织对胰岛素异常敏感[1]。胰岛素是迄今为止发现的最重要的代谢类激素,属于结构相关蛋白超家族(superfamily of structurallyrelated proteins),与其相关的物质还包括胰岛素样生长因子(insulin-like growth fac

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