轻度认知障碍和阿尔茨海默病患者扣带回~1H-MRS的对照研究

发布时间：2018-01-10 14:39

本文关键词：轻度认知障碍和阿尔茨海默病患者扣带回~1H-MRS的对照研究　出处：《东南大学学报(医学版)》2015年05期 　论文类型：期刊论文

【摘要】：目的:探讨轻度认知障碍(MCI)和阿尔茨海默病(AD)患者扣带回代谢物的改变及分布规律,以帮助理解疾病病理改变。方法:使用Achieva 3.0 T TX双梯度双射频源磁共振成像系统、SENSE-8-HEAD线圈,对性别、年龄和教育程度匹配的20例AD患者(AD组)、25例MCI患者(MCI组)及22例正常老年人(对照组,NC组)进行双侧扣带回多体素2D-PRESS1H-MRS扫描。比较3组间双侧扣带回的N-乙酰天门冬氨酸(NAA)/肌酸(Cr)、肌醇(MI)/Cr、MI/NAA值的差异。结果:3组比较只有MI/Cr值的差异有统计学意义,组间比较提示MCI组和AD组的MI/Cr值均高于NC组(P0.05),AD组的MI/NAA值高于NC组(P0.05),NAA/Cr值3组间差异未见统计学意义。扣带回MI/Cr值与Mo CA评分呈显著负相关,MI/NAA值与MMSE评分呈负相关。结论:在AD和MCI患者中扣带回MI/Cr值明显升高,与认知功能呈负相关,MI变化较NAA变化更早更明显,有助于AD早期诊断。
[Abstract]:Objective: to investigate the changes and distribution of cingulate metabolites in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods: Achieva 3.0T TX dual-gradient dual-source magnetic resonance imaging system was used to detect the SENSE-8-HEAD coil on sex. Age and education level matched 20 AD patients with AD group (25 patients with MCI) and 22 normal elderly (control group). The bilateral cingulate gyrus was scanned with 2D-PRESS1H-MRS. The NAA and creatine in the bilateral cingulate gyrus were compared among the three groups. The difference of the value of inositol / inositol / inositol / inositol / cr / min / NAA. Results only the difference of MI/Cr value in the three groups was statistically significant. The MI/Cr value of MCI group and AD group was higher than that of NC group P0.05AD group (P 0.05). There was no significant difference in NAA/Cr value among the three groups. The cingulate gyrus MI/Cr value was negatively correlated with Mo CA score. Conclusion: the MI/Cr value of cingulate gyrus increased significantly in AD and MCI patients, and negatively correlated with cognitive function. The change of MI was earlier and more obvious than that of NAA, which was helpful for the early diagnosis of AD.
【作者单位】：南京医科大学鼓楼临床医学院医学影像科;南京大学医学院附属鼓楼医院神经内科;南京医科大学鼓楼临床医学院神经内科;南京大学医学院附属鼓楼医院医学影像科;
【分类号】：R749.16
【正文快照】： 阿尔茨海默病(Alzheimer's disease,AD)是一种起病隐匿的神经系统退行性疾病,其患病率逐年升高,对家庭和社会危害严重。其以大脑皮质形成大量老年斑和神经元纤维缠结为主要病理特征,皮质是病变原发部位,病变过程早期即累及海马、扣带回。该病目前病因尚不明确,临床诊断缺乏特

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