首诊强迫症患者工作记忆与血清微量元素的关系

发布时间：2018-01-15 06:19

本文关键词：首诊强迫症患者工作记忆与血清微量元素的关系　出处：《中国临床心理学杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的:探讨首诊强迫症患者工作记忆特点及其与血清微量元素的关系。方法:采用数字广度、2-back任务、视觉空间位置记忆和Stroop色-字测试分别对33名首发未服药强迫症患者与31名正常对照进行测量,并测定两组被试血清中微量元素铜(Cu)、锌(Zn)、钙(Ca)、磷(P)、镁(Mg)、铁(Fe)的水平。比较患者组与对照组之间工作记忆的差异及工作记忆与微量元素间的相关性。结果:1患者组数字广度顺背、倒背、总分均较正常对照组差;患者组2-back任务、视觉空间位置记忆测试得分低于对照组;患者组Stroop色-词测验中读字色(Stroop-CW)完成时间长于正常对照。2患者组的微量元素Zn含量显著低于对照组。3患者组Y-BOCS得分与血清Zn含量呈负相关;数字广度倒背、总分及2-back任务正确数与血清Zn含量呈正相关。结论:首诊强迫症患者存在工作记忆损害,且患者血清中Zn含量与工作记忆缺陷可能具有密切关联。
[Abstract]:Objective: To investigate the characteristics of working memory in first-episode patients with obsessive-compulsive disorder and its relationship with serum trace elements. Methods: using the 2-back task, digit span, visual spatial memory and Stroop color word test respectively in 33 first-episode OCD patients and 31 normal controls were measured, and the determination of the two groups of trace elements of copper in serum (Cu), zinc (Zn), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe) level. The correlation between working memory between patient group and control group, and working memory and between trace elements. Results: 1 patients with digit span. The back, total score were compared with normal control group; group 2-back, visual spatial memory test scores than the control group; group Stroop color word test color word reading (Stroop-CW) completion time is longer than normal trace elements content of Zn in.2 group was significantly lower than the control group.3 group Y-BOC There was a negative correlation between S score and serum Zn content. There was a positive correlation between digit width, total score and 2-back task correct number and serum Zn content. Conclusion: there is working memory impairment in patients with obsessive compulsive disorder, and the serum Zn content may be closely related to working memory deficits.

【作者单位】：暨南大学附属第一医院精神医学科;暨南大学管理学院;暨南大学第一临床医学院;
【基金】：教育部人文社科研究规划基金项目(13YJA190008)
【分类号】：R749.7
【正文快照】： 强迫症(obsessive-compulsive disorder,OCD)以有意识的自我强迫和反强迫同时存在为特征,分为强迫思维和强迫行为两大类[1]。结合OCD患者临床表现来看,其思维固着、动作重复、控制力减退等特点均和工作记忆损伤密切相关[2]。目前,国外在这方面的研究已初具规模,但国内多集中于

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