阿立哌唑治疗利培酮所致高催乳素血症女性患者的量效关系

发布时间：2018-01-15 08:18

本文关键词：阿立哌唑治疗利培酮所致高催乳素血症女性患者的量效关系　出处：《中国新药杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的:评估不同剂量阿立哌唑治疗利培酮所致女性精神分裂症患者高催乳素血症的疗效及安全性。方法:61例利培酮所致高催乳素血症女性精神分裂症患者,随机分至阿立哌唑5 mg组(n=16)、10 mg组(n=15)、20 mg组(n=15)和安慰剂组(n=15),维持原有利培酮剂量不变,随访8周。于基线及第2,4和8周末检测血清催乳素(PRL)水平,于基线及8周末评定阳性和阴性症状量表(PANSS)、Barnes静坐不能评定量表(BAS)、Simpson-Angus量表(SAS)及UKU副作用评定量表(UKU)。结果:第8周末,各阿立哌唑剂量组PRL水平均较治疗前显著下降(P0.01),而安慰剂组治疗前后PRL水平无统计学差异。第8周末,阿立哌唑10 mg组和20 mg组PRL下降率、正常率均显著高于阿立哌唑5 mg组和安慰剂组(P0.01),而阿立哌唑10 mg组与20 mg组之间无统计学显著差异。研究终点,4组PANSS,CGI-S,SAS和BAS评分及不良反应发生率均无显著性差异。结论:阿立哌唑可有效治疗利培酮所致女性精神分裂症患者的高催乳素血症,最佳治疗剂量为10 mg·d-1。
[Abstract]:Objective: to evaluate the efficacy and safety of aripiprazole in the treatment of hyperprolactinemia in women with risperidone-induced schizophrenia. Aripiprazole 5 mg group was randomly divided into two groups: aripiprazole 5 mg group (n = 16) and placebo group (n = 15), and the original dose of risperidone remained unchanged in 10 mg group (n = 15) and placebo group (n = 20). The serum prolactin prolactin (PRL) levels were measured at baseline and at the end of 4 and 8 weeks, and PANSSs were assessed at baseline and at the end of 8 weeks. Barnes sit-down scale and UKU side-effect rating scale were used. Results: at the end of the 8th week. The level of PRL in each aripiprazole group was significantly lower than that before treatment (P 0.01), but there was no significant difference in PRL level in the placebo group before and after treatment. The decrease rate of PRL in 10 mg and 20 mg groups of aripiprazole was significantly higher than that of aripiprazole 5 mg group and placebo group (P 0.01). There was no significant difference between 10 mg and 20 mg groups of aripiprazole. There was no significant difference in SAS and BAS scores and the incidence of adverse reactions. Conclusion: aripiprazole is effective in the treatment of hyperprolactinemia in female schizophrenic patients induced by risperidone. The best therapeutic dose was 10 mg 路d -1.
【作者单位】：北京大学回龙观临床医学院;
【基金】：优秀人才基金(2009D003014000001) 北京市医管局重点医学专业发展计划(ZYLX201409) 北京市科技计划项目(D121100005012005)
【分类号】：R749.3
【正文快照】： 利培酮所致高催乳素血症发生率高达70%~100%,且女性显著高于男性。高催乳素血症可能引起闭经、泌乳、男子乳房发育、性功能障碍、骨质疏松等,从而严重限制其临床应用[1]。近年来,多项临床试验证实[2-5],联用多巴胺受体部分激动剂阿立哌唑能有效改善利培酮所致的高催乳素血症。

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