DTI纤维束分析对阿尔茨海默症的研究

发布时间：2018-01-22 01:32

本文关键词： 阿尔茨海默症轻度认知障碍基于纤维束空间统计方法各向异性分数弥散张量成像　出处：《东南大学学报(医学版)》2016年04期 　论文类型：期刊论文

【摘要】：目的:观察阿尔茨海默症(AD)患者、轻度认知障碍(MCI)患者和正常老年人间白质纤维束差异及FA值分布与认知量表评分的关系,以研究认知障碍与全脑纤维束损害的关系并探讨其病理机制。方法:对25例AD患者(AD组)、29例MCI患者(MCI组)和34例正常对照老年人(NC组)使用Achieva 3.0 T TX磁共振进行磁共振弥散张量成像(DTI)扫描,采用FSL软件对3组被试者进行基于纤维束空间统计(TBSS)分析和与量表评分的相关性分析。结果:与NC组比较,MCI组和AD组纤维束FA值均有降低,其中AD组FA值降低区域更广泛;研究发现了被试者FA值与MMSE评分及Mo CA评分呈正相关的区域。结论:AD患者和MCI患者脑内多发白质纤维束损害,FA值改变可能反映认知障碍严重程度,FA值差异对AD的早期诊断具有价值。
[Abstract]:Objective: to observe the difference of white matter fiber bundle and the relationship between FA distribution and cognitive scale score in patients with Alzheimer's disease (AD), patients with mild cognitive impairment (MCI) and normal elderly. Objective: to study the relationship between cognitive impairment and the damage of the whole brain fiber bundle and its pathological mechanism. Methods: 25 patients with AD were treated with AD. 29 MCI patients (MCI group) and 34 normal elderly controls (NC group) were examined with Achieva 3.0T TX magnetic resonance imaging (TX). FSL software was used to analyze the spatial statistics of fiber bundle and the correlation with the score of the scale. Results: compared with NC group. The FA value of fiber bundle in MCI group and AD group was decreased, especially in AD group. The study found that there was a positive correlation between FA value and MMSE score and Mo CA score in subjects. Conclusion multiple white matter bundle lesions in brain were found in patients with AD and MCI. The change of FA value may reflect the severity of cognitive impairment and the difference of FA value may be valuable for early diagnosis of AD.
【作者单位】：东南大学医学电子学实验室;南京大学医学院附属鼓楼医院医学影像科;中国科学院自动化研究所模式识别国家重点实验室;南京大学医学院附属鼓楼医院神经内科;
【分类号】：R749.16
【正文快照】： (1.Laboratory of Medical Electronics,Southeast University,Nanjing 210096,China;2.Department ofRadiology,Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China;3.National Laboratory of Pattern Recognition,Institute of Aut

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