米氮平联合草酸艾司西酞普兰片治疗抑郁症的临床疗效及安全性评价

发布时间：2018-01-29 01:36

本文关键词： 抑郁症米氮平草酸艾司西酞普兰汉密尔顿抑郁量表项蒙哥马利抑郁评定量表　出处：《中国临床药理学杂志》2015年13期 　论文类型：期刊论文

【摘要】：目的评价不同剂量米氮平联合草酸艾司西酞普兰片治疗抑郁症的疗效及安全性。方法入选120例抑郁患者随机分为试验组60例和对照组60例。对照组口服米氮平15 mg·d-1+草酸艾司西酞普兰10 mg·d-1,试验组口服米氮平30 mg·d-1+草酸艾司西酞普兰10 mg·d-1,疗程8周。比较2组患者治疗前,治疗后2,4,6,8周汉密尔顿抑郁量表17项(HAMD-17)评分、蒙哥马利抑郁评定量表(MADRS)评分、临床疗效及不良反应。结果治疗后,2组患者HAMD-17评分及MADRS评分均显著降低,试验组患者HAMD-17评分及MADRS评分显著低于对照组(P0.05)。试验组治疗有效率显著高于对照组(93.3%vs 83.3%)(P0.05)。2组患者口干、乏力、恶心、头晕、嗜睡等不良反应发生率比较差异无统计学意义(P0.05);试验组体重增加率显著高于对照组(P0.05)。结论大剂量(30 mg·d-1)米氮平联合草酸艾司西酞普兰片治疗抑郁症效果优于小剂量(15 mg·d-1)米氮平联合草酸艾司西酞普兰片,但易导致患者体重增加。
[Abstract]:Objective to evaluate the efficacy and safety of different doses of miazapine combined with oxalcitalopram in the treatment of depression. Methods 120 patients with depression were randomly divided into trial group (n = 60) and control group (n = 60). Rice nitride 15. Mg 路d -1 oxalate 10 mg 路d -1. The experimental group was given metozapine 30 mg 路d -1 oxalate 10 mg 路d -1 for 8 weeks. At 8 weeks, 17 items of Hamilton Depression scale (Hamilton Depression scale), 17 items of Hamilton Depression scale (Hamd-17), Montgomery Depression rating scale (MADRS), clinical efficacy and adverse reactions were evaluated. Both HAMD-17 and MADRS scores were significantly decreased in both groups. The HAMD-17 score and MADRS score of the patients in the trial group were significantly lower than those in the control group (P 0.05). The effective rate of treatment in the trial group was significantly higher than that in the control group (93. 3 vs 83. 3%) (. P0.05n.2 group had dry mouth. The incidence of fatigue, nausea, dizziness and somnolence were not significantly different (P 0.05). The weight gain rate in the trial group was significantly higher than that in the control group (P 0.05). Conclusion the effect of high dose of metozapine combined with oxalcitalopram in the treatment of depression is better than that of low dose (P < 0.05). 15 mg 路d -1) mirtazapine combined with oxalcitalopram tablets. But it can easily lead to weight gain.
【作者单位】：惠州市惠阳区慢性病防治站;
【分类号】：R749.4
【正文快照】： (惠州市惠阳区慢性病防治站,广东惠州516211)OU Qiu-ming,DENG Si-ling(Huizhou Chronic Disease Control Sta-tion in Huiyang District Psychiatry,Huizhou 516211,GuangdongProvince,China)抑郁症是心境障碍的常见类型,临床主要表现为显著而持久的心境低落,具有患病率高、

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