精神分裂症血清胰岛素样生长因子2与临床特征的关系

发布时间：2018-01-29 18:55

本文关键词： 精神分裂症胰岛素样生长因子阴性症状认知功能　出处：《中国神经精神疾病杂志》2015年07期 　论文类型：期刊论文

【摘要】：目的探讨精神分裂症患者血清胰岛素样生长因子2(insulin-like growth factor-2,IGF-2)水平变化及其与临床特征的关系。方法纳入精神分裂症患者51例(患者组)和健康志愿者50名(对照组),采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评估患者的精神症状,连线测试A(trail making test A,TMTA)、数字符号编码测验(digit symbol coding subtest,DSCT)、持续操作测验(continuous performance test,CPT)和Stroop色词测验(Stroop color-word test,SCWT)评估两组的认知功能,使用酶联免疫吸附法测定两组血清IGF-2水平。结果患者组与对照组TMTA、DSCT、CPT和SCWT测试结果均存在统计学差异(P0.05)。患者组血清IGF-2水平低于对照组[(202.7±40.7)ng/m L vs.(365.9±65.5)ng/m L],差异有统计学意义(P0.01);首发和复发患者血清IGF-2水平无统计学差异(P0.05)。患者血清IGF-2水平与PANSS阴性症状分(r=-0.397,P=0.004)、CPT分值(r=0.378,P=0.006)、SCWT单词总数(r=0.289,P=0.040)、SCWT颜色总数(r=0.327,P=0.019)、SCWT色/词总数(r=0.386,P=0.005)的相关性具有统计学意义。结论精神分裂症患者血清IGF-2水平下降与阴性症状和认知损害有关,提示IGF-2参与该病发病过程,可能是评价疾病严重程度的生物学指标。
[Abstract]:Objective to investigate the serum insulin-like growth factor-2 in patients with schizophrenia. Methods 51 schizophrenic patients (patient group) and 50 healthy volunteers (control group) were included. The positive and negative syndrome scale was used to evaluate the mental symptoms of the patients. A trail of making test TMTAA was tested by wire test, and digit symbol coding subtest was tested by digital symbol coding test. Continuous performance test. The cognitive function of the two groups was evaluated by Stroop and Stroop color-word test. Serum IGF-2 levels were measured by Elisa. There was statistical difference between CPT and SCWT test results. The serum IGF-2 level in patients was lower than that in control group (P 0.05). [202.7 卤40.7 ng / mL vs.(365.9 卤65.5 ng / mL, the difference was statistically significant (P 0.01). There was no significant difference in serum IGF-2 levels between the first and recurrent patients (P 0.05). The serum IGF-2 level and PANSS negative symptoms were r-0.397. The CPT score of P0. 004 is 0. 378g / s. The total number of SCWT words is 0. 289 / P0. 040). The total number of SCWT colors is 0.327P0. 019 / total number of words is 0. 386. Conclusion the decrease of serum IGF-2 level in schizophrenic patients is related to negative symptoms and cognitive impairment, suggesting that IGF-2 is involved in the pathogenesis of the disease. It may be a biological indicator to evaluate the severity of the disease.
【作者单位】：江西省精神病院精神科;江西省精神病院实验中心;
【基金】：江西省青年科学基金计划项目(编号:20142BAB215028,20142BAB215025) 南昌市科技支撑计划项目(编号:洪科发计字[2013]203号第15项)
【分类号】：R749.3
【正文快照】： 神经发育假说认为精神分裂症与神经发育障碍有关,遗传因素和母孕期损伤可通过影响大脑发育导致个体在青春期后出现精神分裂症症状[1]。胰岛素样生长因子(insulin-like growth factor,IGFs)是一类多功能细胞增殖调控因子,在神经生长和发育过程中发挥重要作用[2]。IGFs包括IGF-1

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