珠海市1.5～3岁孤独症谱系障碍患病率及危险因素研究

发布时间：2018-01-29 20:45

本文关键词： 孤独症谱系障碍患病率珠海市儿童　出处：《中国儿童保健杂志》2014年06期 　论文类型：期刊论文

【摘要】：目的了解珠海市1.5~3岁孤独症谱系障碍(Autism Spectrum Disorders,ASD)的患病率及相关危险因素。方法随机抽取在珠海市生活的1.5~3岁儿童共5 500人,使用自编问卷和改良婴幼儿孤独症筛查量表中文修订版进行初筛;对结果阳性者由专科医师根据临床观察及儿童孤独症评定量表评定结果进行确诊;最后统计分析ASD患儿的患病率及危险因素。结果本次调查ASD患病率为29.45/104(95%CI为15.41/104~44.86/104),均为典型孤独症患儿,男女比例为6∶1。ASD组与非ASD组在性别、家庭收入、父母文化程度、母孕期间是否服用特殊药物(避孕药物、抗精神病药物、抗癫痫病药物等)、母孕期间是否补充叶酸、父亲年龄的分布上存在明显不同,差异有统计学意义(P0.05);回归分析结果显示家庭收入偏低、母孕期间服用特殊药物、母孕期间未补充叶酸及出生时父亲年龄偏高(35岁)或偏低(25岁)等可能为ASD的危险因素。结论珠海市1.5~3岁ASD患病率低于国内外的报道水平;母亲怀孕时避免使用特殊药物、积极补充叶酸,避免父亲年龄过高或过低可能有助于降低ASD患病率。
[Abstract]:Objective to investigate Autism Spectrum Disorders of 3 years old autistic children in Zhuhai. Methods the prevalence and risk factors of ASD.Methods A total of 5 500 children aged from 1.5 to 3 years living in Zhuhai were randomly selected. Self-made questionnaire and modified Chinese version of infant autism screening scale were used for primary screening. The patients with positive results were diagnosed according to clinical observation and children autism rating scale. Results the prevalence of ASD in this survey was 29.45 / 104 / 95 and CI was 15.41 / 104 / 44.86 / 104 / 104). . The ratio of male to female was 6: 1. 1. The sex, family income, education level of parents, whether the mother took special drugs (contraception, antipsychotic) in ASD group and non-ASD group were 6: 1. 1. There were significant differences in the distribution of father's age and whether folic acid was added to the mother during pregnancy, and the difference was statistically significant (P 0.05). Regression analysis showed that the family income was low and the mother took special drugs during pregnancy. During pregnancy without folic acid supplementation and father's age at birth is higher than 35 years) or younger than 25 years). Conclusion the prevalence rate of ASD in Zhuhai is lower than that reported at home and abroad. Avoiding the use of special drugs during pregnancy, actively supplementing folic acid, and avoiding overage or overage of fathers may help reduce the prevalence of ASD.
【作者单位】：珠海市妇幼保健院儿童心理行为科;珠海市妇幼保健院门诊部;珠海市妇幼保健院产科三区;
【基金】：珠海市科技计划项目(201311140051)
【分类号】：R749.94
【正文快照】： 孤独症谱系障碍(autism spectrum disorders,ASD)是一类儿童广泛性发育障碍性疾病,以社会互动性交往障碍、语言沟通障碍以及局限和刻板的兴趣和行为模式为基本特征,包括孤独症、阿斯伯格综合征、雷特综合征、儿童瓦解性精神障碍和未分类的广泛性发育障碍等亚型,其中以孤独症和

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