多动宁胶囊联合妥泰治疗小儿多发性抽动症的临床疗效观察

发布时间：2018-02-04 15:52

本文关键词： 多发性抽动症中西医结合多动宁胶囊妥泰　出处：《福建中医药大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：观察多动宁胶囊联合妥泰治疗小儿多发性抽动症的临床疗效。方法：采用非盲法随机对照试验设计方案,筛选符合入组标准的多发性抽动症患儿60例。按随机原则分为A组：单用中药治疗组(多动宁胶囊)20例；B组：单用西药治疗组(妥泰)20例;C组：试验组(多动宁胶囊联合妥泰)20例。观察A、B、C三组治疗前后的耶鲁综合抽动严重程度量表(YGTSS)评分及治疗后相关副反应,从而比较三组治疗的临床疗效。结果：(1)试验组(C组)临床控制3例,显效14例,好转2例,无效1例,总有效率95%；单用西药治疗组(B组)临床控制0例,显效12例,好转5例,无效3例,总有效率85%；单用中药治疗组(A组)临床控制0例,显效10例,好转6例,无效4例,总有效率80%。试验组疗效明显优于单用西药治疗组及单用中药治疗组(P0.05)。(2)副反应情况：单用西药治疗组(B组)有3例出现厌食,1例出现头晕,经添加助消化及滋补肾阴的中成药后症状缓解,单用中药治疗组(A组)及试验组(C组)未见明显副反应发生。结论：通过试验研究,试验组(C组)治疗小儿多发性抽动症的临床疗效较为显著,可更好地降低患儿YGTSS评分和治疗后相关副反应,临床总有效率95%,优于单用西药治疗组(B组)和单用中药治疗组(A组)。多动宁胶囊联合妥泰治疗小儿多发性抽动症可作为临床治疗的较好选择。
[Abstract]:Objective: to observe the clinical effect of Duohuning capsule combined with topiramate in the treatment of children with multiple tic syndrome. Methods: a non-blind randomized controlled trial scheme was used to screen 60 children with multiple tic syndrome according to the criteria of admission. According to the random principle, 60 children were divided into two groups: group A, treated with traditional Chinese medicine alone (20 cases), and group A (20 cases) treated with traditional Chinese medicine alone. Group B: 20 cases were treated with western medicine alone; Group C: experimental group (20 cases) treated with Duoxunning capsule combined with topiramate. The YGTSS scores and related side effects were observed before and after treatment in group A BX C. The clinical effects of the three groups were compared. Results in the test group, 3 cases were clinically controlled, 14 cases were effective, 2 cases were improved, 1 case was ineffective, and the total effective rate was 95%. There were 0 cases of clinical control, 12 cases of remarkable effect, 5 cases of improvement and 3 cases of ineffectiveness. The total effective rate was 85%. There were 0 cases of clinical control, 10 cases of remarkable effect, 6 cases of improvement and 4 cases of ineffectiveness. The total effective rate was 80. The curative effect of the trial group was significantly better than that of the western medicine treatment group and the traditional Chinese medicine treatment group (P0.05. 2) side effects: there were 3 cases of anorexia in the western medicine alone treatment group (group B). One case had dizziness, the symptoms were relieved after adding the Chinese patent medicine of digestive aid and tonifying kidney yin, but no side effects were found in group A (treated with traditional Chinese medicine alone) and group C (test group). Conclusion: through the experimental study, the clinical effect of group C) in treating children with multiple tic syndrome is more significant, which can better reduce the YGTSS score of children and related side effects after treatment. The total clinical effective rate was 95%, which was better than that in group B (treated with western medicine alone) and group A (group A) treated with traditional Chinese medicine alone. The combination of Duohunning capsule and topiramate could be used as a better choice in the treatment of children with multiple tic syndrome.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.94

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