氟西汀干预对大鼠抑郁模型海马代谢的影响

发布时间：2018-02-09 14:52

  本文关键词： 抑郁 氟西汀 氢质子磁共振波谱分析　出处：《临床神经病学杂志》2014年01期 　论文类型：期刊论文

【摘要】：目的探讨氟西汀干预对大鼠抑郁模型的海马代谢的影响。方法 45只SD大鼠随机分为正常对照组(n=15)以及抑郁组(n=30)。抑郁组又被分为干预亚组(n=15)及未干预亚组(n=15)。采用慢性不可预知应激及孤养的方法建立抑郁模型。在制模成功后不干预亚组大鼠腹腔注射生理盐水2.0 ml/d,干预亚组大鼠腹腔注射盐酸氟西汀溶液5.0 mg/(kg·d);均持续4周。于干预前后对各组大鼠进行氢质子磁共振波谱分析检查,并进行比较。结果抑郁组大鼠双侧海马N-乙酰天冬氨酸(NAA)/肌酸(Cr)及谷氨酸复合物(Glx)/Cr显著低于正常对照组,胆碱复合物(Cho)/Cr及肌醇(mI)/Cr显著高于正常对照组(P0.05~0.01)。干预亚组双侧海马的NAA/Cr及Glx/Cr显著高于未干预亚组双侧海马的Cho,ho/Cr及右侧海马的mI/Cr显著低于未干预亚组(P0.05~0.01)。与干预前比较,干预亚组干预后双侧海马NAA/Cr及Glx/Cr显著升高(均P0.05);未干预亚组双侧海马Cho/Cr及mI/Cr显著升高,NAA/Cr及Glx/Cr显著降低(均P0.05)。结论氟西汀能够改善海马神经细胞的谷氨酸循环及肌醇磷酸循环,恢复神经元及神经胶质细胞的功能。
[Abstract]:Objective to investigate the effect of fluoxetine intervention on hippocampal metabolism in rats with depression. Methods Forty-five SD rats were randomly divided into normal control group (n = 15) and depression group (n = 30). The depression model was established by the methods of chronic unpredictable stress and solitary nourishment. The rats in the control group were given intraperitoneal injection of normal saline 2.0 ml / d and the intervention subgroup received intraperitoneal injection of fluoxetine hydrochloride (5.0 mg/(kg 路d) for 4 weeks. Before and after intervention, the rats in each group were examined by proton magnetic resonance spectroscopy. Results in the depression group, the levels of NAANAA / creatine Cr) and glutamate complex in bilateral hippocampus of the depression group were significantly lower than those in the normal control group. The levels of NAA/Cr and Glx/Cr in the bilateral hippocampus of the intervention group were significantly higher than those of the control group (P0.050.01). The mI/Cr of the bilateral hippocampus of the intervention group was significantly lower than that of the non-intervention subgroup (P0.05P0.01), and the mI/Cr of the right hippocampus was significantly lower than that of the non-intervention subgroup. In the intervention subgroup, the NAA/Cr and Glx/Cr in the bilateral hippocampus increased significantly (all P 0.05), and the Cho/Cr and mI/Cr in the hippocampus in the control group increased significantly (P < 0.05). Conclusion Fluoxetine can improve the glutamate and inositol phosphoric acid circulation in the hippocampal neurons. To restore the function of neurons and glial cells.
【作者单位】： 江苏大学附属医院神经内科;江苏大学附属医院影像科;
【分类号】：R749.4

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