阿托伐他汀对氟西汀治疗中、重度抑郁症的增效作用

发布时间：2018-02-09 16:42

本文关键词： 抑郁症阿托伐他汀氟西汀　出处：《中国新药与临床杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的评价阿托伐他汀对氟西汀治疗中、重度抑郁症的增效作用。方法中、重度抑郁症患者67例,分为阿托伐他汀和氟西汀联合治疗组(治疗组)34例、氟西汀单药治疗组(对照组)33例。疗程共6周,两组患者前2周口服氟西汀20 mg·d~(-1),随后4周口服氟西汀40 mg·d~(-1),治疗组同时服用阿托伐他汀20 mg·d~(-1)。评定治疗期间不同时点汉密顿抑郁量表(HAMD)评分,检测治疗前后天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果治疗后,两组HAMD量表评分随时间减少(均P0.01),治疗组的HAMD评分比对照组降低更明显(P0.05,P0.01)。治疗组TC、TG较对照组降低(均P0.01),HDL-C、LDL-C、ALT、AST组间比较无显著差异(均P0.05)。治疗期间两组均无严重不良事件发生。结论氟西汀联合阿托伐他汀治疗在6周内较氟西汀单药治疗能更有效减轻中、重度抑郁症的临床症状,阿托伐他汀可能是抑郁症的有效辅助治疗用药。
[Abstract]:Objective to evaluate the synergistic effect of Atto vastatin on severe depression in the treatment of fluoxetine. Methods 67 patients with severe depression were divided into two groups: Atto vastatin and fluoxetine combined treatment group (34 cases). Fluoxetine monotherapy group (control group, 33 cases) for 6 weeks, Two groups of patients were given fluoxetine 20 mg 路dhuan-1 for the first 2 weeks, then 40 mg 路dl-1 for fluoxetine for 4 weeks. The treatment group was also given Atto vastatin 20 mg 路df-1. The Hamilton Depression scale (Hamd) score was assessed at different time points during the treatment period. The levels of aspartate transaminase (AST), alanine aminotransferase (alt), total cholesterol (TC), triglyceride (TGN), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were measured before and after treatment. The HAMD score of the two groups decreased with time (P 0.01), the HAMD score of the treatment group was significantly lower than that of the control group, and the TG of the treatment group was lower than that of the control group (P 0.01). There was no significant difference between the two groups (P 0.05). There was no significant difference between the two groups during the treatment period. Conclusion Fluoxetine combined with Atto vastatin is more effective than fluoxetine in 6 weeks. In clinical symptoms of severe depression, Atto vastatin may be an effective adjuvant therapy for depression.
【作者单位】：新乡医学院第二附属医院;深圳市康宁医院;
【基金】：河南省卫生科技创新型人才工程专项经费(编号4173)
【分类号】：R749.4

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