精神分裂症与代谢综合征的相关性研究

发布时间：2018-02-09 16:55

本文关键词： 精神分裂症代谢综合征相关性　出处：《中国全科医学》2014年34期 　论文类型：期刊论文

【摘要】：目的探讨精神分裂症与代谢综合征(metabolic syndrome,MS)的关系。方法于2013年9—12月从六安市第二人民医院精神卫生中心2012年6月—2013年6月收治住院的2 899例精神疾病患者中,抽取符合纳入、排除标准的773例。据2004年中华医学会糖尿病分会(CDS,2004)MS诊断标准,按是否合并MS将其分为MS组和无MS组。采用自制一般情况调查表,分别对两组患者的性别、年龄、住院天数、病程、抗精神病药物种类、空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、血压(BP)、体质指数(BMI)及吸烟史等资料进行比较。结果 773例精神分裂症患者中有40.8%(315/773)合并MS。MS组患者的FPG、TG、BMI及血压水平高于无MS组,HDL-C水平低于无MS组,差异有统计学意义(P0.01)。精神分裂症患者MS的患病率比较,男性患者的患病率(161/409,39.4%)和女性患者的患病率(154/364,42.3%)差异无统计学意义(P0.05);50岁的患者的患病率(42/77,54.5%)高于30岁(83/222,37.4%)和30~50岁(190/474,40.1%)的患者,差异有统计学意义(P0.05);无吸烟史患者的患病率(162/456,35.5%)低于吸烟史10年(50/100,50.0%)和≥10年的患者(103/217,47.5%),差异有统计学意义(P0.05);病程10年的患者的患病率(128/271,47.2%)高于病程5年(62/172,36.0%)和5~10年的患者(125/330,37.9%),差异有统计学意义(P0.05)。使用不同抗精神病药物的患者MS的患病率各不相同,但差异无统计学意义(P0.05)。多因素回归分析显示,性别、年龄、吸烟史及精神分裂症病程对精神分裂症是否合并MS的影响有统计学意义(P0.05)。结论精神分裂症患者MS的患病率较一般人群要高,尤其是女性、年龄大、吸烟及病程长的患者,使用抗精神病药物也可能是导致MS发病的危险因素。
[Abstract]:Objective to investigate the relationship between schizophrenia and metabolic syndrome (MS). Methods from 2013 to December, we selected 2 899 patients with mental diseases admitted from the Mental Health Center of the second people's Hospital of Luan City from June 2012 to June 2013. According to the diagnostic criteria of MS in 2004, the patients were divided into MS group and non-MS group according to whether they were combined with MS. The self-made general information questionnaire was used to analyze the sex, age and hospitalization days of the two groups. Course of disease, types of antipsychotics, Fasting blood glucose (FBG), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), blood pressure (BP), body mass index (BMI) and smoking history were compared. Results 40.8% of 773 schizophrenic patients with MS.MS had higher MS.MS BMI and blood pressure. The level of HDL-C in MS free group was lower than that in no MS group. There was no significant difference in the prevalence of MS between male patients and female patients. There was no statistically significant difference in the prevalence of MS between male patients and female patients. There was no significant difference in the prevalence rate of P0.055-50 patients aged 50 years (P 0.05% 7754.545) higher than that of patients aged 30 years (8322227.44%) and 3050 years old (190-4740.10%). The difference was statistically significant (P 0.05); the prevalence rate of patients without smoking history was 162 / 4565.5kW) lower than that of patients with 10 years of smoking history (50 / 100 / 50.0) and those with more than 10 years (P = 103 / 21747.5m), the difference was statistically significant (P = 0.05a); the prevalence rate of patients with 10 years course of disease was 128271or 47.2) higher than that of patients with disease course of 5 years (62172n / 36.0) and 5- 10 years (P < 0.05). There was a statistically significant difference in the prevalence of MS among patients with different antipsychotics. But the difference was not statistically significant (P 0.05). Multivariate regression analysis showed that sex, age, The history of smoking and the course of schizophrenia have statistical significance on the influence of schizophrenia with MS. Conclusion the prevalence rate of MS in schizophrenic patients is higher than that in the general population, especially in females, older patients, smoking patients and patients with long course of disease. The use of antipsychotics may also be a risk factor for MS.
【作者单位】：安徽医科大学第一附属医院内分泌科;六安市第二人民医院内分泌科;六安市第二人民医院精神卫生中心;
【分类号】：R749.3

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