尼莫地平联合奥拉西坦胶囊治疗T2DM患者合并轻度血管性认知障碍的疗效观察

发布时间：2018-02-09 17:32

本文关键词： 糖尿病型血管性认知障碍 C肽尼莫地平奥拉西坦　出处：《重庆医学》2014年35期 　论文类型：期刊论文

【摘要】：目的观察尼莫地平联合奥拉西坦胶囊治疗2型糖尿病(T2DM)患者合并轻度血管性认知障碍(mVCI)的临床疗效。方法筛选72例T2DM合并mVCI患者,分为对照组和观察组,每组36例。对照组常规治疗加用尼莫地平片40mg,每日3次;观察组常规治疗加用尼莫地平40mg,每日3次,奥拉西坦胶囊800mg,每日2次;疗程为6个月。记录治疗前、后两组患者的空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1C)及C肽水平,并采用蒙特利尔认知评估量表(MoCA)对两组患者进行认知功能评估。结果治疗前两组患者均有C肽水平下降及轻度认知障碍,差异无统计学意义(P0.05)。治疗后两组患者的C肽水平、MoCA总分及记忆功能、执行功能、注意力认知亚项评分均较治疗前提高,差异有统计学意义(P0.05);且观察组较对照组改善更为显著(P0.01)。结论尼莫地平联合奥拉西坦胶囊能显著改善T2DM合并mVCI患者的认知功能,其疗效优于单用尼莫地平。
[Abstract]:Objective to observe the clinical effect of nimodipine combined with olaxetam capsule in the treatment of type 2 diabetes mellitus (T2DM) with mild vascular cognitive impairment (VCI). Methods 72 cases of T2DM with mVCI were selected and divided into two groups: control group and observation group. There were 36 cases in each group. The control group was treated with 40 mg nimodipine 3 times a day, the observation group was treated with 40 mg nimodipine 3 times a day, and the oxacitam capsule 800 mg twice a day. The course of treatment was 6 months. The levels of fasting blood glucose (FBGG), 2 h postprandial blood glucose (2 h PBGN), HbA1C (glycosylated hemoglobin) and C-peptide were measured in the latter two groups. The cognitive function of the two groups was evaluated with the Montreal Cognitive Assessment scale (MOCA). Results before treatment, the levels of C-peptide and mild cognitive impairment were decreased in both groups. There was no significant difference between the two groups (P 0.05). After treatment, the total score of C peptide and the scores of memory function, executive function, attention cognition subitem in the two groups were higher than those before treatment. Conclusion Nimodipine combined with olaxetam capsule can significantly improve the cognitive function of T2DM patients with mVCI, and the curative effect of Nimodipine alone is better than that of nimodipine alone.
【作者单位】：重庆市肿瘤研究所神经内科;
【基金】：重庆市卫生局基金资助项目(2011-2-363)
【分类号】：R587.1;R749.13

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