含可待因的止咳药水滥用成瘾患者静息态下全脑白质微结构的改变

发布时间：2018-02-10 15:18

本文关键词： 可待因止咳药水滥用成瘾脑白质微结构静息态弥散张量成像技术　出处：《中山大学学报(医学科学版)》2017年01期 　论文类型：期刊论文

【摘要】：【目的】探讨含可待因的止咳药水滥用成瘾患者在静息状态下全脑白质显微结构的改变,同时探讨含可待因的止咳药水成瘾患者脑白质微结构的改变与其成瘾时间的关系。【方法】本研究纳入了30名含可待因的止咳药水滥用成瘾患者和30名健康对照。观察含可待因的止咳药水滥用成瘾患者全脑白质FA值(分数各向异性),MD值(平均扩散系数)的改变,应用Pearson相关分析得到了含可待因的止咳药水滥用成瘾患者全脑白质微结构改变与成瘾时间的关系。【结果】与正常对照组相比,慢性含可待因止咳药水滥用成瘾患者双侧内囊前支白质纤维(ALIC)平均FA值显著降低,而双侧海马、双侧岛叶、右侧前扣带皮层及右侧颞上回平均MD显著升高。ALIC平均FA值与成瘾时间具有显著相关性。【结论】慢性含可待因止咳药水滥用成瘾患者全脑白质微结构存在不同程度改变,这种结构连接的破坏随着其成瘾时间而持续进展。
[Abstract]:[objective] to investigate the changes of microstructures in the white matter of whole brain in patients with cough drug abuse addiction under resting state. At the same time, the relationship between the changes of white matter microstructure and the time of addiction in patients with cough drug addiction with codeine was studied. [methods] the study included 30 patients with cough drug abuse with codeine and 30 healthy controls. To observe the changes of FA (fractional anisotropy / MD) (mean diffusion coefficient) in the white matter of patients with cough drug abuse addiction with codeine. Pearson correlation analysis was used to study the relationship between the changes of white matter microstructure and the time of addiction in patients with addiction to cough potion with codeine. [results] compared with the normal control group, the relationship between the changes of white matter microstructure and the time of addiction was obtained. The mean FA value of ALICI in patients with chronic drug abuse with codeine was significantly lower than that in bilateral hippocampal, bilateral insular lobes. The mean MD of right anterior cingulate cortex and right superior temporal gyrus were significantly increased. The mean FA value of ALIC was significantly correlated with the time of addiction. [conclusion] the microstructures of white matter in patients with addiction to chronic codeine cough drug abuse have different degrees. The destruction of this structural connection continues to progress over time of addiction.
【作者单位】：广东药科大学数学系;新疆自治区人民医院北院影像科;广东省第二人民医院影像科;广东药科大学药科学院药理系;
【基金】：广东省科技计划项目(2013B021800172) 广东省医学科学技术研究基金项目(A2016147) 广东省数据科学工程技术研究中心开放项目(2016KF02) 广州市人体数据科学重点实验室(201605030011)
【分类号】：R749.61

【相似文献】