慢性丙型病毒性肝炎伴发焦虑抑郁症患者血清载脂蛋白B的表达水平及意义研究

发布时间：2018-02-14 06:28

本文关键词： 肝炎丙型慢性焦虑抑郁症载脂蛋白B类　出处：《中国全科医学》2016年09期 　论文类型：期刊论文

【摘要】：目的探讨慢性丙型病毒性肝炎(CHC)伴发焦虑抑郁症患者血清载脂蛋白B(Apo B)表达水平及意义。方法选取2010年1月—2014年6月于四川省达州市中心医院住院的CHC患者100例为CHC组,另选取同时期本院体检健康者100例为对照组。采用医院焦虑和抑郁量表评估焦虑/抑郁症程度,采用Olympus 3200型全自动生化分析仪检测血清Apo B水平。比较对照组及不同焦虑或抑郁症程度CHC患者血清Apo B水平的差异。结果 100例CHC患者中无焦虑组54例、轻度焦虑组20例、中重度焦虑组26例,无抑郁症组74例、轻度抑郁症组9例、中重度抑郁症组17例。无焦虑组、轻度焦虑组、中重度焦虑组患者血清Apo B水平较对照组下降(P0.05);无焦虑组、轻度焦虑组、中重度焦虑组患者血清Apo B水平比较,差异无统计学意义(P0.05)。无抑郁症组、轻度抑郁症组、中重度抑郁症组患者血清Apo B水平较对照组下降(P0.05);轻度抑郁症组、中重度抑郁症组患者血清Apo B水平较无抑郁症组下降(P0.05);中重度抑郁症组患者血清Apo B水平较轻度抑郁症组下降(P0.05)。结论 CHC患者伴发焦虑抑郁症与血清Apo B水平降低相关,血清Apo B水平下降与抑郁症程度相关,而与焦虑程度无明显相关关系。
[Abstract]:Objective to investigate the expression and significance of serum apolipoprotein (ApoB) Apo B in patients with chronic hepatitis C (CHC) accompanied with anxiety depression. Methods 100 CHC patients hospitalized in Dazhou Central Hospital of Sichuan Province from January 2010 to June 2014 were selected as CHC group. In addition, 100 healthy patients in the same period were selected as control group. The degree of anxiety and depression was evaluated by hospital anxiety and depression scale. The serum Apo B levels were measured by Olympus 3200 automatic biochemical analyzer. The serum Apo B levels were compared between the control group and CHC patients with different degree of anxiety or depression. Results there were 54 cases of no anxiety group and 20 cases of mild anxiety group in 100 cases of CHC. There were 26 cases of moderate and severe anxiety group, 74 cases of non-depression group, 9 cases of mild depression group and 17 cases of moderate and severe depression group. The serum Apo B level of patients in non-anxiety group, mild anxiety group and moderate and severe anxiety group was lower than that in control group (P 0.05), no anxiety group, no anxiety group, no anxiety group, no anxiety group, no anxiety group, no anxiety group, There was no significant difference in serum Apo B levels between mild anxiety group and moderate and severe anxiety group (P 0.05). The serum Apo B level in mild depression group, mild depression group, moderate and severe depression group was lower than that in control group (P 0.05), while in mild depression group, the serum Apo B level in mild depression group was lower than that in control group (P 0.05). The level of serum Apo B in patients with moderate and severe depression was lower than that in patients without depression (P 0.05A), and the level of serum Apo B in patients with moderate and severe depression was lower than that in patients with mild depression (P 0.05). Conclusion the level of serum Apo B in patients with CHC associated with anxiety depression is correlated with the decrease of serum Apo B levels. The decrease of serum Apo B level was correlated with the degree of depression, but not with the degree of anxiety.
【作者单位】：四川省达州市中心医院消化内科;重庆医科大学附属第一医院神经内科;重庆医科大学附属第一医院血液内科;
【基金】：国家自然科学基金面上项目(81371310) 重庆市卫生局面上项目(2012-2-033)
【分类号】：R512.63;R749

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