前列地尔联合丁苯酞对老年2型糖尿病合并认知功能障碍的疗效观察

发布时间：2018-02-14 13:48

本文关键词： 前列地尔型糖尿病合并认知功能障碍机制研究丁苯酞联合治疗　出处：《中国医院药学杂志》2017年13期 　论文类型：期刊论文

【摘要】：目的:观察前列地尔联合丁苯酞治疗老年2型糖尿病合并认知功能障碍的治疗效果,为2型糖尿病合并认知功能障碍老年患者的临床治疗提供帮助。方法:选取临床收治的2型糖尿病合并认知功能障碍老年患者100例,按随机数字表法分为:观察组(50例)和对照组(50例),对照组老年患者给予常规治疗,在此基础上,观察组老年患者给予丁苯酞和前列地尔的联合治疗,检测治疗前后2组老年患者MoCA评分、血小板参数、血液动力学及神经因子的变化。结果:与治疗前相比,2组老年患者神经因子(S-100β和NSE)、血小板参数(PDW、MPV、PLCR和PCT)和R1显著降低,MoCA评分、神经因子(NGF和NTF)和血液动力学指标(v_(max)、v_(min)和Q)显著升高,差异存在统计学意义(P0.05)。经过联合治疗后观察组老年患者MoCA评分、神经因子(NGF和NTF)和血液动力学指标(v_(max)、v_(min)和Q)显著高于治疗后对照组,神经因子(S-100β和NSE)、血小板参数(PDW、MPV、PLCR和PCT)和R1显著低于治疗后对照组,差异存在统计学意义(P0.05)。结论:丁苯酞和前列地尔的联合治疗能够改善2型糖尿病合并认知功能障碍老年患者的血小板状况,提高患者的MoCA评分和神经机能同时加速血液流动,对2型糖尿病合并认知功能障碍老年患者的临床治疗具有重要的意义。
[Abstract]:Objective: to observe the effect of alprostadil combined with butyphthalide in the treatment of senile type 2 diabetes mellitus with cognitive dysfunction. Methods: 100 elderly patients with type 2 diabetes complicated with cognitive dysfunction were selected. According to the random digital table method, the patients in the observation group were divided into two groups: the observation group (n = 50) and the control group (n = 50). The elderly patients in the control group were given routine treatment. On this basis, the elderly patients in the observation group were treated with the combination of butylphthalide and alprostadil. Before and after treatment, the changes of MoCA score, platelet parameters, hemodynamics and neurocytokines were measured. Results: compared with those before treatment, the scores of neurocytokines S-100 尾 and NSE, platelet parameters, such as MoCA, MPV, PLCR and R1, and R1 decreased significantly in the two groups. The levels of NGF and NTF) and hemodynamic indexes were significantly increased, and the difference was statistically significant (P 0.05). After combined treatment, the MoCA score of the elderly patients in the observation group was significantly higher than that in the control group. The levels of NGF, NTF) and hemodynamic indexes, such as NGF and NTF) and hemodynamic indexes, were significantly higher than those in the control group after treatment, and the levels of neurofactor S-100 尾 and NSEP, platelet parameters such as PDWMMPVPLCR and PCT1 were significantly lower than those in the control group after treatment. Conclusion: the combined treatment of butylphthalide and alprostadil can improve the platelet status of the elderly patients with type 2 diabetes mellitus with cognitive impairment, improve the MoCA score and nerve function of the patients, and accelerate blood flow at the same time. The clinical treatment of type 2 diabetes mellitus with cognitive dysfunction is of great significance.
【作者单位】：新疆医科大学附属中医医院干二科;
【分类号】：R587.2;R749.2

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