CLU基因多态性与汉族人阿尔茨海默病的关联研究

发布时间：2018-02-24 07:17

本文关键词： CLU 多态性阿尔茨海默病　出处：《青岛大学》2011年硕士论文　论文类型：学位论文

【摘要】：目的探讨中国汉族人群CLU基因多态性与散发性阿尔茨海默病(sporadic Alzheimer's disease,SAD)的相互关系。方法应用病例对照的研究方法,我们共入选SAD患者324例,同期年龄和性别完全匹配的对照组388例。多态性基因分型采用MALDI-TOF质谱技术,检测rs2279590,rs11136000and rs9331888基因型、等位基因多态性的分布。结果CLU基因rs9331888多态性最小等位基因可显著增加SAD的发病风险(OR=1.39,95%CI=1.13-1.72,P=0.002).上述关联性在载脂蛋白E ε4等位基因非携带者中,较携带者更加明显。Logistic回归分析揭示,无论在显性还是隐性模型中,rs9331888多态性,与散发型阿尔茨海默病均有显著的相关性。在散发性阿尔茨海默病患者组和对照组之间,没有发现rs2279590和rs11136000基因型和等位基因频率的显著差异。单体型分析,确定了风险单倍型(CCG)(OR=1.66,95%CI为1.33-2.07,P0.001)和保护单体型(CCC)(OR=0.70,95%CI为0.57-0.81,P值0.001)。结论CLU基因多态性与汉族人阿尔茨海默病的易感性相关联。
[Abstract]:Objective to investigate the relationship between CLU gene polymorphism and sporadic Alzheimer's disease of Alzheimer's disease (sad) in Chinese Han population. Methods A case-control study was conducted in 324 SAD patients and 388 age-sex matched controls. The genotypes of Rs2279590 rs11136000 and rs9331888 were detected by MALDI-TOF mass spectrometry. Distribution of allelic polymorphism. Results the minimal allele of rs9331888 polymorphism of CLU gene could significantly increase the risk of SAD. Logistic regression analysis showed that the association was more obvious in apolipoprotein E 蔚 4 alleles than in carriers. Rs9331888 polymorphism was significantly associated with sporadic Alzheimer's disease in both dominant and recessive models. There was no significant difference in genotype and allele frequency between rs2279590 and rs11136000. Haplotype analysis showed that the risk haplotype was 1.33-2.07P0.001 (CI = 1.33-2.07) and the haplotype was 0.700.7095 / CI (P = 0.57-0.81P = 0.001). Conclusion CLU gene polymorphism is associated with susceptibility to Alzheimer's disease in Han Chinese.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R749.16

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