五积散与小剂量阿立哌唑治疗抗精神病药物所致痰湿型闭经的临床研究

发布时间：2018-02-25 21:48

本文关键词： 抗精神病药物痰湿型闭经肥胖指数五积散阿立哌唑　出处：《中国中西医结合杂志》2014年12期 　论文类型：期刊论文

【摘要】：目的探讨五积散与小剂量阿立哌唑治疗抗精神病药物所致痰湿型闭经的临床疗效及安全性。方法选因服抗精神病药物引起药源性闭经和(或)泌乳的女性精神分裂症患者70例,随机分为治疗组和对照组,各35例。两组患者在服用抗精神病药物的同时,治疗组给予五积散治疗,对照组给予阿立哌唑(5 mg,1次/日)治疗。治疗前后时测定催乳素(prolactin,PRL)水平、肥胖指数[体重、腰围、体重指数(BMI)及腰臀比(WHR),并进行疗效评定。结果两组总完成率为95.71%;治疗组33例,总有效率为93.94%(31/33);对照组34例,总有效率为91.18%(31/34),两组比较差异无统计学意义(P0.05)。与治疗前比较,两组治疗后PRL水平均下降,差异均有统计学意义(均P0.01),治疗后两组间比较差异无统计学意义(P0.05)。与治疗前比较,治疗组治疗后体重、BMI、腰围、WHR明显降低,并较对照组降低明显,差异有统计学意义(P0.05)。对照组治疗前后体重、BMI、腰围、WHR比较,差异无统计学意义(P0.05)。结论五积散与阿立哌唑均能降低痰湿型闭经的精神分裂症患者的高PRL水平,且疗效相当,但五积散在降低肥胖指数方面作用更明显。
[Abstract]:Objective to investigate the clinical efficacy and safety of Wuji Powder and low dose aripiprazole in the treatment of phlegm dampness type amenorrhea caused by antipsychotic drugs. Methods 70 female patients with dysmenorrhea and / or lactation caused by antipsychotic drugs were selected. The two groups were randomly divided into treatment group (n = 35) and control group (n = 35). The patients in the treatment group were treated with Wuji Powder while the patients in the treatment group were treated with arripiprazole 5 mg / d. The prolactinine prolactinine PRL level was measured before and after treatment. Obesity index [body weight, waist circumference, body mass index (BMI) and waist-hip ratio (WHR) were evaluated. Results the total completion rate of the two groups was 95.71.The total effective rate of the treatment group (33 cases) was 93.9441 / 33, and that of the control group (34 cases). The total effective rate was 91.18 / 31 / 34, and there was no significant difference between the two groups (P 0.05). Compared with before treatment, the PRL level of the two groups decreased significantly (P 0.01), and there was no significant difference between the two groups after treatment (P 0.05), and there was no significant difference between the two groups after treatment (P 0.01), and there was no significant difference between the two groups after treatment (P 0.05). After treatment, the weight and waist circumference of WHR in the treatment group were significantly lower than those in the control group, and the difference was statistically significant (P 0.05). Conclusion both WJS and aripiprazole can reduce the high PRL level of schizophrenic patients with phlegm-dampness type amenorrhea, and the curative effect is similar, but WJS plays a more important role in reducing obesity index.
【作者单位】：浙江萧山医院精神卫生中心;
【分类号】：R749.3

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