帕罗西汀联合喹硫平治疗广泛性焦虑障碍的疗效与安全性

发布时间：2018-02-27 01:36

本文关键词： 广泛性焦虑障碍帕罗西汀喹硫平　出处：《中国临床药理学杂志》2014年06期 　论文类型：期刊论文

【摘要】：目的评价帕罗西汀联合小剂量喹硫平治疗广泛性焦虑障碍的疗效及安全性。方法 140例广泛性焦虑障碍患者随机分为治疗组(帕罗西汀联合小剂量喹硫平,71例)和对照组(帕罗西汀组,69例)。分别于治疗前及治疗后第1,2,4,6,8周末用汉密尔顿焦虑量表(HAMA)评定疗效,治疗副反应量表(TESS)评定药物不良反应,匹兹堡睡眠质量指数(PSQI)进行睡眠状况自评。结果观察8周,治疗组和对照组在治愈率(70.4%/68.1%)、显著改善率(15.5%/13.0%)、进步率(8.5%/10.1%)、无效率(5.6%/8.7%)方面差异无统计学意义(P0.05)。治疗组在治疗1周末HAMA总分即有明显下降(P0.05);对照组从2周末开始明显下降(P0.05)。治疗组1,2,4周末精神焦虑因子较对照组差异有统计学意义(P0.05或P0.01);2,4周末躯体焦虑因子分较对照组差异有统计学意义(P0.05或P0.01)。治疗后,治疗组与对照组PSQI评分差异有统计学意义(P0.05或P0.01)。2组均未发现明显药物不良反应。结论帕罗西汀联合小剂量喹硫平治疗广泛性焦虑症起效早、安全性好,患者依从性好。
[Abstract]:Objective to evaluate the efficacy and safety of paroxetine combined with low dose quetiapine in the treatment of generalized anxiety disorder. Methods 140 patients with generalized anxiety disorder were randomly divided into treatment group (71 cases with paroxetine combined with low dose quetiapine). And the control group (paroxetine group, 69 cases) were evaluated with Hamilton anxiety scale (Hama) before and after treatment. Treatment side effects scale (TESS) was used to assess adverse drug reactions and Pittsburgh Sleep quality Index (PSQI) was used to evaluate sleep status. There was no significant difference in the cure rate between the treatment group and the control group in the cure rate of 70.4% / 68.1%, the improvement rate of 15.5g / 13.0%, the improvement rate of 8.5% / 10.1%, the inefficiency of 5.6% -8.7%). There was no significant difference in the total score of HAMA between the treatment group and the control group at the end of the first week of treatment (P 0.05); in the control group, the total score of HAMA decreased significantly from the end of week 2 to the end of the week of treatment. Compared with the control group, the mental anxiety factors in the treatment group were significantly different from those in the control group at the end of 4 weeks. The scores of somatic anxiety factors at the end of the week were significantly higher than those in the control group (P 0.05 or P 0.01). After treatment, the scores of somatic anxiety factors in the treatment group were significantly higher than those in the control group. The difference of PSQI score between the treatment group and the control group was statistically significant (P0.05) or (0.01). 2. Conclusion Paroxetine combined with low dose quinolipine is effective and safe in the treatment of generalized anxiety disorder, and the compliance of the patients is good.
【作者单位】：安徽医科大学医学心理系;安徽医科大学杭州精神卫生临床学院;
【基金】：杭州市卫生局基金资助项目(2012A038)
【分类号】：R749.4

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