有氧训练对阿尔茨海默病患者认知功能和日常生活活动能力的影响

发布时间：2018-02-27 16:00

本文关键词： 有氧训练阿尔茨海默病认知功能日常生活活动能力　出处：《中国康复医学杂志》2014年12期 　论文类型：期刊论文

【摘要】：目的:探讨有氧训练对阿尔茨海默病(AD)患者认知功能、日常生活活动能力的影响,并摸索有效的、具体的有氧运动方案。方法:选取门诊就诊和招募的60例AD患者为研究对象,随机分为有氧训练组和对照组,每组30例。有氧训练方案采用踩车的运动方式,强度为运动试验中最大心率的70%(中等强度),每次训练时间为持续40min(包括热身运动5min,靶强度运动30min,整理运动5min),3次/周,为期3个月。对照组不进行有氧训练干预,仅进行日常活动。两组试验前后采用简易智力状态检查(MMSE)、阿尔茨海默病认知功能评定量表(ADAS-cog)、阿尔茨海默病协作研究日常能力量表(ADCS-ADL),以及老年性痴呆生活质量量表(QOL-AD)进行认知功能、日常生活活动能力和生活质量的评估。结果:共54例AD患者(有氧训练组26例,对照组28例)完成全部试验,有氧训练组AD患者在训练结束后MMSE、ADCS-ADL、QOL-AD评分均较训练前提高,ADAS-cog分值较训练前下降,与基线比较有显著性差异(P0.05);而对照组AD患者试验前后MMSE、ADAS-cog、ADCS-ADL、QOL-AD均无显著性差异(P0.05)。训练后两组间比较,有氧训练组MMSE、ADAS-cog、ADCS-ADL、QOL-AD评分较对照组均有显著性差异(P0.05)。Spearman秩相关性分析有氧训练组患者QOL-AD分值的提高与ADCS-ADL分数改变有相关性,而与ADAS-cog分数变化无相关性。结论:本研究中采用的药物辅助下中等强度的有氧训练方案对AD患者的认知功能、日常生活活动能力具有改善作用。
[Abstract]:Objective: to explore the effect of aerobic training on cognitive function and activity of daily living (ADL) in patients with Alzheimer's disease (AD), and to explore an effective and specific aerobic exercise program. They were randomly divided into aerobic training group and control group with 30 cases in each group. The intensity was 70 parts of the maximum heart rate in the exercise test (moderate intensity). The duration of each training was 40 minutes (including warm-up exercise for 5 minutes, target intensity exercise for 30 minutes, finishing exercise for 5 minutes or three times a week for 3 months). The control group did not take aerobic training intervention. Only daily activities were carried out. Before and after the two groups were given simple mental state examination (MMSE), Alzheimer's disease cognitive function assessment scale (ADAS-cog), Alzheimer's disease collaborative research daily ability scale (ADCS-ADLL), and Alzheimer's disease quality of life scale (QOL). QOL-AD) for cognitive function, Evaluation of ADL and quality of life. Results: a total of 54 AD patients (26 in aerobic training group and 28 in control group) completed the whole test. In aerobic training group, the scores of ADCS-ADLLQOL-AD in AD patients after training were higher than those before training, and the scores of ADAS-cog in aerobic training group were lower than those before and after training, and there was a significant difference between the two groups (P 0.05), while in the control group, there was no significant difference in ADCS-ADLQOL-AD between the two groups before and after the training, while in the control group, there was no significant difference between the two groups before and after training (P 0.05). A significant difference in the score of ADCS-ADLL QOL-AD between the aerobic training group and the control group; the correlation between the increase of QOL-AD score and the change of ADCS-ADL score in aerobic training group was found. Conclusion: the moderate intensity aerobic training regimen used in this study can improve the cognitive function and ADL ability of AD patients.
【作者单位】：南京医科大学第一附属医院神经内科;南京医科大学第一附属医院康复医学中心;沭阳县人民医院神经内科;马鞍山市中心医院神经内科;
【基金】：国家自然科学基金(30901578) 江苏省“六大人才高峰”第八批高层次人才资助项目江苏省高校“青蓝工程”中青年学术带头人培养对象项目(JX2161015003) 江苏省卫生厅“科教兴卫工程”重点人才项目(RC2011072) 江苏省卫生厅“科教兴卫工程”开放课题(XK20200905) 苏州市科技局科技发展计划项目(SYSD2011044)
【分类号】：R749.16;R493

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