多奈哌齐对精神分裂症患者认知功能的影响

发布时间：2018-02-27 16:35

本文关键词： 精神分裂症认知功能多奈哌齐　出处：《中南大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的探讨抗精神病药合并胆碱酯酶抑制剂多奈哌齐对精神分裂症患者认知功能的疗效。研究方法本研究采用随机双盲安慰剂对照的方法,56例稳定期精神分裂症患者随机分为抗精神病药合并多奈哌齐组(研究组,28例)和抗精神病药合并安慰剂组(对照组,28例),在原有抗精神病药物的基础上分别加用多奈哌齐(5mg/d)或安慰剂口服治疗,治疗12周。于治疗基线及治疗12周末进行认知功能(包括处理速度、言语学习及记忆、视觉学习及记忆、工作记忆、注意警觉、执行功能六个纬度)、精神症状(阳性与阴性症状量表,the Positive and Negative Syndrome Scale PANSS)、社会功能(个人与社会表现量表,Personal and Social Performance, PSP)及不良反应评估,主要评估指标为认知功能及阴性症状。结果 1.治疗12周末与基线相比,多奈哌齐组的处理速度、视觉学习和记忆、工作记忆测验成绩均有显著改善(P0.05)；PSP总分改善显著(P0.05)；PANSS总分及阴性症状分量表分无显著变化(P0.05)： 2.治疗12周末与基线相比,安慰剂组在认知功能测验成绩均无显著改善；PSP总分、PANSS总分及其阴性症状分量表分无显著变化(P0.05)； 3.两组改善值比较,多奈哌齐组在认知功能的处理速度、视觉学习和记忆、工作记忆方面显著优于安慰剂组(P0.05)；PSP总分改善、PANSS总分及其阴性症状分量表分变化值两组无显著差异(P0.05)： 4.不良反应的发生率两组差异无统计学意义(P0.05),未发生严重不良反应。结论 1.抗精神病药合并多奈哌齐可以改善病情稳定期精神分裂症患者的处理速度、视觉学习和记忆、工作记忆等认知功能； 2.抗精神病药合并多奈哌齐具有良好的临床用药安全性。
[Abstract]:Purpose. To investigate the effect of antipsychotic drugs combined with cholinesterase inhibitor Donepezil on cognitive function in patients with schizophrenia. Research method. In this study, 56 patients with stable schizophrenia were randomly divided into two groups: antipsychotics combined with Donepezil (study group, 28 cases) and antipsychotics combined with placebo (control group, n = 28). On the basis of the original antipsychotic drugs, they were treated orally with Donepezil 5 mg / d or placebo, respectively. 12 weeks of treatment. Cognitive function (including processing speed, speech learning and memory, visual learning and memory, working memory, attention alertness) is performed at baseline and 12 weeks of treatment. Six dimensions of executive function, the Positive and Negative Syndrome Scale PANSSN, the personal and Social performance (PSPs) and the adverse reactions were evaluated. The main evaluation indexes were cognitive function and negative symptoms. Results. 1.Compared with the baseline at the end of 12 years, the scores of processing speed, visual learning and memory, working memory test in the Donepezil group were significantly improved. The total score of P0.05 and PSP were significantly improved. There was no significant change in the total score of PANSS and the subscale of negative symptoms in the group of Donepezil (P 0.05). 2.Compared with baseline at the end of 12 years, the scores of cognitive function test in placebo group were not significantly improved, the total score of PSP and the total score of PANSS and the subscale of negative symptoms had no significant change (P 0.05). 3.Compared with the improvement values of the two groups, there was no significant difference between the two groups in the processing speed of cognitive function, visual learning and memory, working memory and the total score of PSP in placebo group. There was no significant difference between the two groups in improving the total score of PANSS and its negative symptom subscale (P 0.05). 4. There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion. 1. Antipsychotic drugs combined with Donepezil can improve the cognitive function, such as processing speed, visual learning and memory, working memory and so on; 2. Antipsychotic drugs combined with Donepezil have good clinical safety.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.3

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