石杉碱甲及尼莫地平联合多奈哌齐治疗轻中度老年血管性痴呆的疗效

发布时间：2018-02-28 01:46

本文关键词： 血管性痴呆石杉碱甲尼莫地平多奈哌齐认知功能　出处：《中国老年学杂志》2015年12期 　论文类型：期刊论文

【摘要】：目的探讨石杉碱甲、尼莫地平和多奈哌齐三种可逆性胆碱酯酶抑制剂(AchEI)联合使用对轻中度老年血管性痴呆患者认知功能的影响。方法选取该院轻中度老年血管性痴呆患者150例,随机分为五组,每组30例。其中四组为观察组,分别使用石杉碱甲联合尼莫地平(A组)、石杉碱甲联合多奈哌齐(B组)、尼莫地平联合多奈哌齐(C组)、石杉碱甲和尼莫地平联合多奈哌齐治疗(D组);另一组为对照组,不予任何与改善智能相关的药物。采用简易精神状态量表、词语延迟回忆、本顿视觉保持、数字符号替换及数字广度倒数分、连线A、言语流畅性、画钟等测验评价用药3、6、9个月时患者的认知功能。结果各观察组词语延迟回忆测验、本顿视觉保持测验、数字符号替换及数字广度倒数分测验、连线A测验以及精神状态量表(MMSE)得分持续改善。结论 AchEI的联合使用可改善轻中度老年血管性痴呆患者的认知功能。
[Abstract]:Objective to investigate the effect of Huperzine A, nimodipine and Donepezil on cognitive function of patients with mild and moderate vascular dementia. They were randomly divided into five groups with 30 cases in each group. Huperzine A combined with nimodipine A group, Huperzine A combined with Donepezil group B, nimodipine combined with Donepezil group C, Huperzine A and nimodipine combined with Donepezil were used to treat group D, the other group was control group. No drugs related to the improvement of intelligence. Simple mental state scale, word delay recall, Benton visual retention, digit symbol replacement and countdown of digit span, line A, speech fluency, Results the cognitive function of the patients was evaluated at the age of 6 months and 9 months after treatment. Results the words delayed recall test, the Benton visual retention test, the digit symbol replacement and the digit span reciprocal test were used in each observation group. Conclusion the combined use of AchEI can improve the cognitive function of patients with mild to moderate vascular dementia.
【作者单位】：许昌学院医学院;许昌市中医院药剂科;
【基金】：河南省卫生厅项目(No.WJ1054)
【分类号】：R749.16

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